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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8IUE

RNA polymerase III pre-initiation complex melting complex 1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ADNA-directed RNA polymerase III subunit RPC1polymer1390155860.11UniProt (O14802)
Pfam (PF05000)
Pfam (PF04998)
Pfam (PF04997)
Pfam (PF00623)
Pfam (PF04983)
In PDB		Homo sapiens (human)RNA polymerase III subunit C1,DNA-directed RNA polymerase III largest subunit,DNA-directed RNA polymerase III subunit A,RNA polymerase III 155 kDa subunit,RPC155,RNA polymerase III subunit C160
2BDNA-directed RNA polymerase III subunit RPC2polymer1133127953.91UniProt (Q9NW08)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF04566)
Pfam (PF04567)
Pfam (PF00562)
Pfam (PF04560)
In PDB		Homo sapiens (human)RNA polymerase III subunit C2,C128,DNA-directed RNA polymerase III 127.6 kDa polypeptide,DNA-directed RNA polymerase III subunit B
3CDNA-directed RNA polymerases I and III subunit RPAC1polymer34639301.71UniProt (O15160)
Pfam (PF01193)
Pfam (PF01000)
In PDB		Homo sapiens (human)RNA polymerases I and III subunit AC1,AC40,DNA-directed RNA polymerases I and III 40 kDa polypeptide,RPA40,RPA39,RPC40
4DDNA-directed RNA polymerase III subunit RPC9polymer14816894.01UniProt (O75575)
Pfam (PF03874)
In PDB		Homo sapiens (human)RNA polymerase III subunit C9,Calcitonin gene-related peptide-receptor component protein,HsC17
5EDNA-directed RNA polymerases I, II, and III subunit RPABC1polymer21024584.21UniProt (P19388)
Pfam (PF03871)
Pfam (PF01191)
In PDB		Homo sapiens (human)RNA polymerases I,II,and III subunit ABC1,DNA-directed RNA polymerase II 23 kDa polypeptide,DNA-directed RNA polymerase II subunit E,RPB5 homolog,XAP4
6FDNA-directed RNA polymerases I, II, and III subunit RPABC2polymer12714491.01UniProt (P61218)
Pfam (PF01192)
In PDB		Homo sapiens (human)RNA polymerases I,II,and III subunit ABC2,DNA-directed RNA polymerase II subunit F,DNA-directed RNA polymerases I,and III 14.4 kDa polypeptide,RPABC14.4,RPB14.4,RPB6 homolog,RPC15
7GDNA-directed RNA polymerase III subunit RPC8polymer20422938.81UniProt (Q9Y535)
Pfam (PF03876)
Pfam (PF08292)
In PDB		Homo sapiens (human)RNA polymerase III subunit C8,DNA-directed RNA polymerase III subunit H,RNA polymerase III subunit 22.9 kDa subunit,RPC22.9
8HDNA-directed RNA polymerases I, II, and III subunit RPABC3polymer15017162.31UniProt (P52434)
Pfam (PF03870)
In PDB		Homo sapiens (human)RNA polymerases I,II,and III subunit ABC3,DNA-directed RNA polymerase II subunit H,DNA-directed RNA polymerases I,and III 17.1 kDa polypeptide,RPB17,RPB8 homolog,hRPB8
9IDNA-directed RNA polymerase III subunit RPC10polymer10812338.11UniProt (Q9Y2Y1)
Pfam (PF02150)
Pfam (PF01096)
In PDB		Homo sapiens (human)RNA polymerase III subunit C10,DNA-directed RNA polymerase III subunit K,RNA polymerase III 12.5 kDa subunit,RPC12.5,RNA polymerase III subunit C11,HsC11p,RPC11,hRPC11
10JDNA-directed RNA polymerases I, II, and III subunit RPABC5polymer677655.11UniProt (P62875)
Pfam (PF01194)
In PDB		Homo sapiens (human)RNA polymerases I,II,and III subunit ABC5,DNA-directed RNA polymerase III subunit L,RNA polymerase II 7.6 kDa subunit,RPB7.6,RPB10 homolog
11KDNA-directed RNA polymerases I and III subunit RPAC2polymer13315259.21UniProt (P0DPB6)
Pfam (PF13656)
In PDB		Homo sapiens (human)RNA polymerases I and III subunit AC2,AC19,DNA-directed RNA polymerase I subunit D,RNA polymerase I 16 kDa subunit,RPA16,RPC16,hRPA19
12LDNA-directed RNA polymerases I, II, and III subunit RPABC4polymer587018.21UniProt (P53803)
Pfam (PF03604)
In PDB		Homo sapiens (human)RNA polymerases I,II,and III subunit ABC4,ABC10-alpha,DNA-directed RNA polymerase II subunit K,RNA polymerase II 7.0 kDa subunit,RPB7.0,RPB10alpha
13MDNA-directed RNA polymerase III subunit RPC5polymer70880004.01UniProt (Q9NVU0)
Pfam (PF04801)
Pfam (PF19725)
In PDB		Homo sapiens (human)RNA polymerase III subunit C5,DNA-directed RNA polymerase III 80 kDa polypeptide
14NDNA-directed RNA polymerase III subunit RPC4polymer31735195.61UniProt (P05423)
Pfam (PF05132)
In PDB		Homo sapiens (human)RNA polymerase III subunit C4,DNA-directed RNA polymerase III subunit D,Protein BN51,RNA polymerase III 47 kDa subunit,RPC53 homolog
15ODNA-directed RNA polymerase III subunit RPC3polymer53460692.61UniProt (Q9BUI4)
Pfam (PF08221)
Pfam (PF05645)
Pfam (PF22536)
Pfam (PF20912)
In PDB		Homo sapiens (human)RNA polymerase III subunit C3,DNA-directed RNA polymerase III subunit C,RNA polymerase III 62 kDa subunit,RPC62
16PDNA-directed RNA polymerase III subunit RPC6polymer31635726.91UniProt (Q9H1D9)
Pfam (PF05158)
In PDB		Homo sapiens (human)RNA polymerase III subunit C6,DNA-directed RNA polymerase III subunit F,RNA polymerase III 39 kDa subunit,RPC39
17QDNA-directed RNA polymerase III subunit RPC7polymer22325953.51UniProt (O15318)
Pfam (PF11705)
In PDB		Homo sapiens (human)RNA polymerase III subunit C7,DNA-directed RNA polymerase III subunit G,RNA polymerase III 32 kDa apha subunit,RPC32-alpha,RNA polymerase III 32 kDa subunit,RPC32
18XHuman gene for U 6 RNApolymer464143512.51GenBank (37562)Homo sapiens
19YDNA (74-MER)polymer464143039.51GenBank (37562)Homo sapiens
201snRNA-activating protein complex subunit 1polymer36843074.51UniProt (Q16533)
Pfam (PF09808)
In PDB		Homo sapiens (human)SNAPc subunit 1,Proximal sequence element-binding transcription factor subunit gamma,PSE-binding factor subunit gamma,PTF subunit gamma,Small nuclear RNA-activating complex polypeptide 1,snRNA-activating protein complex 43 kDa subunit,SNAPc 43 kDa subunit
213snRNA-activating protein complex subunit 3polymer41146812.61UniProt (Q92966)
Pfam (PF12251)
In PDB		Homo sapiens (human)SNAPc subunit 3,Proximal sequence element-binding transcription factor subunit beta,PSE-binding factor subunit beta,PTF subunit beta,Small nuclear RNA-activating complex polypeptide 3,snRNA-activating protein complex 50 kDa subunit,SNAPc 50 kDa subunit
224snRNA-activating protein complex subunit 4polymer1469159645.21UniProt (Q5SXM2)
Pfam (PF13921)
In PDB		Homo sapiens (human)SNAPc subunit 4,Proximal sequence element-binding transcription factor subunit alpha,PSE-binding factor subunit alpha,PTF subunit alpha,snRNA-activating protein complex 190 kDa subunit,SNAPc 190 kDa subunit
23UTATA-box-binding proteinpolymer33937729.91UniProt (P20226)
Pfam (PF00352)
In PDB		Homo sapiens (human)TATA sequence-binding protein,TATA-binding factor,TATA-box factor,Transcription initiation factor TFIID TBP subunit
24VTranscription factor IIIB 50 kDa subunitpolymer41946587.41UniProt (Q9HAW0)
Pfam (PF08271)
Pfam (PF21886)
In PDB		Homo sapiens (human)TFIIIB50,hTFIIIB50,B-related factor 2,BRF-2,hBRFU
25WTranscription factor TFIIIB component B'' homologpolymer2624294301.41UniProt (A6H8Y1)
Pfam (PF15963)
In PDB		Homo sapiens (human)Transcription factor IIIB 150,TFIIIB150,Transcription factor-like nuclear regulator
26A, B, I, J, L...ZINC IONnon-polymer65.48Chemie (ZN)
27AMAGNESIUM IONnon-polymer24.31Chemie (MG)
28PIRON/SULFUR CLUSTERnon-polymer351.61Chemie (SF4)
Sequence modifications
I: 1 - 108 (UniProt: Q9Y2Y1)
PDBExternal DatabaseDetails
Ala 24Ser 24variant
N: 1 - 398 (UniProt: P05423)
PDBExternal DatabaseDetails
-Lys 160deletion
-Asp 161deletion
-Asp 162deletion
-Phe 163deletion
-Leu 164deletion
-Asp 165deletion
-Asp 166deletion
-Pro 167deletion
-Gly 168deletion
-Leu 169deletion
-Arg 170deletion
-Asn 171deletion
-Asp 172deletion
-Thr 173deletion
-Arg 174deletion
-Asn 175deletion
-Met 176deletion
-Pro 177deletion
-Val 178deletion
-Gln 179deletion
-Leu 180deletion
-Pro 181deletion
-Leu 182deletion
-Ala 183deletion
-His 184deletion
-Ser 185deletion
-Gly 186deletion
-Trp 187deletion
-Leu 188deletion
-Phe 189deletion
-Lys 190deletion
-Glu 191deletion
-Glu 192deletion
-Asn 193deletion
-Asp 194deletion
-Glu 195deletion
-Pro 196deletion
-Asp 197deletion
-Val 198deletion
-Lys 199deletion
-Pro 200deletion
-Trp 201deletion
-Leu 202deletion
-Ala 203deletion
-Gly 204deletion
-Pro 205deletion
-Lys 206deletion
-Glu 207deletion
-Glu 208deletion
-Asp 209deletion
-Met 210deletion
-Glu 211deletion
-Val 212deletion
-Asp 213deletion
-Ile 214deletion
-Pro 215deletion
-Ala 216deletion
-Val 217deletion
-Lys 218deletion
-Val 219deletion
-Lys 220deletion
-Glu 221deletion
-Glu 222deletion
-Pro 223deletion
-Arg 224deletion
-Asp 225deletion
-Glu 226deletion
-Glu 227deletion
-Glu 228deletion
-Glu 229deletion
-Ala 230deletion
-Lys 231deletion
-Met 232deletion
-Lys 233deletion
-Ala 234deletion
-Pro 235deletion
-Pro 236deletion
-Lys 237deletion
-Ala 238deletion
-Ala 239deletion
-Arg 240deletion
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains25
Total formula weight1613732.2
Non-Polymers*Number of molecules10
Total formula weight899.2
All*Total formula weight1614631.4
*Water molecules are not included.

224004

PDB entries from 2024-08-21

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