8IUE
RNA polymerase III pre-initiation complex melting complex 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA-directed RNA polymerase III subunit RPC1 | polymer | 1390 | 155860.1 | 1 | UniProt (O14802) Pfam (PF05000) Pfam (PF04998) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) | Homo sapiens (human) | RNA polymerase III subunit C1,DNA-directed RNA polymerase III largest subunit,DNA-directed RNA polymerase III subunit A,RNA polymerase III 155 kDa subunit,RPC155,RNA polymerase III subunit C160 |
| 2 | B (B) | DNA-directed RNA polymerase III subunit RPC2 | polymer | 1133 | 127953.9 | 1 | UniProt (Q9NW08) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) | Homo sapiens (human) | RNA polymerase III subunit C2,C128,DNA-directed RNA polymerase III 127.6 kDa polypeptide,DNA-directed RNA polymerase III subunit B |
| 3 | C (C) | DNA-directed RNA polymerases I and III subunit RPAC1 | polymer | 346 | 39301.7 | 1 | UniProt (O15160) Pfam (PF01193) Pfam (PF01000) | Homo sapiens (human) | RNA polymerases I and III subunit AC1,AC40,DNA-directed RNA polymerases I and III 40 kDa polypeptide,RPA40,RPA39,RPC40 |
| 4 | D (D) | DNA-directed RNA polymerase III subunit RPC9 | polymer | 148 | 16894.0 | 1 | UniProt (O75575) Pfam (PF03874) | Homo sapiens (human) | RNA polymerase III subunit C9,Calcitonin gene-related peptide-receptor component protein,HsC17 |
| 5 | E (E) | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | polymer | 210 | 24584.2 | 1 | UniProt (P19388) Pfam (PF03871) Pfam (PF01191) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC1,DNA-directed RNA polymerase II 23 kDa polypeptide,DNA-directed RNA polymerase II subunit E,RPB5 homolog,XAP4 |
| 6 | F (F) | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 127 | 14491.0 | 1 | UniProt (P61218) Pfam (PF01192) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC2,DNA-directed RNA polymerase II subunit F,DNA-directed RNA polymerases I,and III 14.4 kDa polypeptide,RPABC14.4,RPB14.4,RPB6 homolog,RPC15 |
| 7 | G (G) | DNA-directed RNA polymerase III subunit RPC8 | polymer | 204 | 22938.8 | 1 | UniProt (Q9Y535) Pfam (PF03876) Pfam (PF08292) | Homo sapiens (human) | RNA polymerase III subunit C8,DNA-directed RNA polymerase III subunit H,RNA polymerase III subunit 22.9 kDa subunit,RPC22.9 |
| 8 | H (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (P52434) Pfam (PF03870) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC3,DNA-directed RNA polymerase II subunit H,DNA-directed RNA polymerases I,and III 17.1 kDa polypeptide,RPB17,RPB8 homolog,hRPB8 |
| 9 | I (I) | DNA-directed RNA polymerase III subunit RPC10 | polymer | 108 | 12338.1 | 1 | UniProt (Q9Y2Y1) Pfam (PF02150) Pfam (PF01096) | Homo sapiens (human) | RNA polymerase III subunit C10,DNA-directed RNA polymerase III subunit K,RNA polymerase III 12.5 kDa subunit,RPC12.5,RNA polymerase III subunit C11,HsC11p,RPC11,hRPC11 |
| 10 | J (J) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (P62875) Pfam (PF01194) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC5,DNA-directed RNA polymerase III subunit L,RNA polymerase II 7.6 kDa subunit,RPB7.6,RPB10 homolog |
| 11 | K (K) | DNA-directed RNA polymerases I and III subunit RPAC2 | polymer | 133 | 15259.2 | 1 | UniProt (P0DPB6) Pfam (PF13656) | Homo sapiens (human) | RNA polymerases I and III subunit AC2,AC19,DNA-directed RNA polymerase I subunit D,RNA polymerase I 16 kDa subunit,RPA16,RPC16,hRPA19 |
| 12 | L (L) | DNA-directed RNA polymerases I, II, and III subunit RPABC4 | polymer | 58 | 7018.2 | 1 | UniProt (P53803) Pfam (PF03604) | Homo sapiens (human) | RNA polymerases I,II,and III subunit ABC4,ABC10-alpha,DNA-directed RNA polymerase II subunit K,RNA polymerase II 7.0 kDa subunit,RPB7.0,RPB10alpha |
| 13 | M (M) | DNA-directed RNA polymerase III subunit RPC5 | polymer | 708 | 80004.0 | 1 | UniProt (Q9NVU0) Pfam (PF04801) Pfam (PF19725) | Homo sapiens (human) | RNA polymerase III subunit C5,DNA-directed RNA polymerase III 80 kDa polypeptide |
| 14 | N (N) | DNA-directed RNA polymerase III subunit RPC4 | polymer | 317 | 35195.6 | 1 | UniProt (P05423) Pfam (PF05132) | Homo sapiens (human) | RNA polymerase III subunit C4,DNA-directed RNA polymerase III subunit D,Protein BN51,RNA polymerase III 47 kDa subunit,RPC53 homolog |
| 15 | O (O) | DNA-directed RNA polymerase III subunit RPC3 | polymer | 534 | 60692.6 | 1 | UniProt (Q9BUI4) Pfam (PF08221) Pfam (PF05645) Pfam (PF22536) Pfam (PF20912) | Homo sapiens (human) | RNA polymerase III subunit C3,DNA-directed RNA polymerase III subunit C,RNA polymerase III 62 kDa subunit,RPC62 |
| 16 | P (P) | DNA-directed RNA polymerase III subunit RPC6 | polymer | 316 | 35726.9 | 1 | UniProt (Q9H1D9) Pfam (PF05158) | Homo sapiens (human) | RNA polymerase III subunit C6,DNA-directed RNA polymerase III subunit F,RNA polymerase III 39 kDa subunit,RPC39 |
| 17 | Q (Q) | DNA-directed RNA polymerase III subunit RPC7 | polymer | 223 | 25953.5 | 1 | UniProt (O15318) Pfam (PF11705) | Homo sapiens (human) | RNA polymerase III subunit C7,DNA-directed RNA polymerase III subunit G,RNA polymerase III 32 kDa apha subunit,RPC32-alpha,RNA polymerase III 32 kDa subunit,RPC32 |
| 18 | R (X) | Human gene for U 6 RNA | polymer | 464 | 143512.5 | 1 | GenBank (37562) | Homo sapiens | |
| 19 | S (Y) | DNA (74-MER) | polymer | 464 | 143039.5 | 1 | GenBank (37562) | Homo sapiens | |
| 20 | T (1) | snRNA-activating protein complex subunit 1 | polymer | 368 | 43074.5 | 1 | UniProt (Q16533) Pfam (PF09808) | Homo sapiens (human) | SNAPc subunit 1,Proximal sequence element-binding transcription factor subunit gamma,PSE-binding factor subunit gamma,PTF subunit gamma,Small nuclear RNA-activating complex polypeptide 1,snRNA-activating protein complex 43 kDa subunit,SNAPc 43 kDa subunit |
| 21 | U (3) | snRNA-activating protein complex subunit 3 | polymer | 411 | 46812.6 | 1 | UniProt (Q92966) Pfam (PF12251) | Homo sapiens (human) | SNAPc subunit 3,Proximal sequence element-binding transcription factor subunit beta,PSE-binding factor subunit beta,PTF subunit beta,Small nuclear RNA-activating complex polypeptide 3,snRNA-activating protein complex 50 kDa subunit,SNAPc 50 kDa subunit |
| 22 | V (4) | snRNA-activating protein complex subunit 4 | polymer | 1469 | 159645.2 | 1 | UniProt (Q5SXM2) Pfam (PF13921) | Homo sapiens (human) | SNAPc subunit 4,Proximal sequence element-binding transcription factor subunit alpha,PSE-binding factor subunit alpha,PTF subunit alpha,snRNA-activating protein complex 190 kDa subunit,SNAPc 190 kDa subunit |
| 23 | W (U) | TATA-box-binding protein | polymer | 339 | 37729.9 | 1 | UniProt (P20226) Pfam (PF00352) | Homo sapiens (human) | TATA sequence-binding protein,TATA-binding factor,TATA-box factor,Transcription initiation factor TFIID TBP subunit |
| 24 | X (V) | Transcription factor IIIB 50 kDa subunit | polymer | 419 | 46587.4 | 1 | UniProt (Q9HAW0) Pfam (PF08271) Pfam (PF21886) | Homo sapiens (human) | TFIIIB50,hTFIIIB50,B-related factor 2,BRF-2,hBRFU |
| 25 | Y (W) | Transcription factor TFIIIB component B'' homolog | polymer | 2624 | 294301.4 | 1 | UniProt (A6H8Y1) Pfam (PF15963) | Homo sapiens (human) | Transcription factor IIIB 150,TFIIIB150,Transcription factor-like nuclear regulator |
| 26 | AA, CA, DA, EA, FA... (A, B, I, J, L...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 27 | BA (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 28 | HA (P) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) |
Sequence modifications
I: 1 - 108 (UniProt: Q9Y2Y1)
N: 1 - 398 (UniProt: P05423)
| PDB | External Database | Details |
|---|---|---|
| Ala 24 | Ser 24 | variant |
| PDB | External Database | Details |
|---|---|---|
| - | Lys 160 | deletion |
| - | Asp 161 | deletion |
| - | Asp 162 | deletion |
| - | Phe 163 | deletion |
| - | Leu 164 | deletion |
| - | Asp 165 | deletion |
| - | Asp 166 | deletion |
| - | Pro 167 | deletion |
| - | Gly 168 | deletion |
| - | Leu 169 | deletion |
| - | Arg 170 | deletion |
| - | Asn 171 | deletion |
| - | Asp 172 | deletion |
| - | Thr 173 | deletion |
| - | Arg 174 | deletion |
| - | Asn 175 | deletion |
| - | Met 176 | deletion |
| - | Pro 177 | deletion |
| - | Val 178 | deletion |
| - | Gln 179 | deletion |
| - | Leu 180 | deletion |
| - | Pro 181 | deletion |
| - | Leu 182 | deletion |
| - | Ala 183 | deletion |
| - | His 184 | deletion |
| - | Ser 185 | deletion |
| - | Gly 186 | deletion |
| - | Trp 187 | deletion |
| - | Leu 188 | deletion |
| - | Phe 189 | deletion |
| - | Lys 190 | deletion |
| - | Glu 191 | deletion |
| - | Glu 192 | deletion |
| - | Asn 193 | deletion |
| - | Asp 194 | deletion |
| - | Glu 195 | deletion |
| - | Pro 196 | deletion |
| - | Asp 197 | deletion |
| - | Val 198 | deletion |
| - | Lys 199 | deletion |
| - | Pro 200 | deletion |
| - | Trp 201 | deletion |
| - | Leu 202 | deletion |
| - | Ala 203 | deletion |
| - | Gly 204 | deletion |
| - | Pro 205 | deletion |
| - | Lys 206 | deletion |
| - | Glu 207 | deletion |
| - | Glu 208 | deletion |
| - | Asp 209 | deletion |
| - | Met 210 | deletion |
| - | Glu 211 | deletion |
| - | Val 212 | deletion |
| - | Asp 213 | deletion |
| - | Ile 214 | deletion |
| - | Pro 215 | deletion |
| - | Ala 216 | deletion |
| - | Val 217 | deletion |
| - | Lys 218 | deletion |
| - | Val 219 | deletion |
| - | Lys 220 | deletion |
| - | Glu 221 | deletion |
| - | Glu 222 | deletion |
| - | Pro 223 | deletion |
| - | Arg 224 | deletion |
| - | Asp 225 | deletion |
| - | Glu 226 | deletion |
| - | Glu 227 | deletion |
| - | Glu 228 | deletion |
| - | Glu 229 | deletion |
| - | Ala 230 | deletion |
| - | Lys 231 | deletion |
| - | Met 232 | deletion |
| - | Lys 233 | deletion |
| - | Ala 234 | deletion |
| - | Pro 235 | deletion |
| - | Pro 236 | deletion |
| - | Lys 237 | deletion |
| - | Ala 238 | deletion |
| - | Ala 239 | deletion |
| - | Arg 240 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 25 |
| Total formula weight | 1613732.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 899.2 | |
| All* | Total formula weight | 1614631.4 |
