8IU2
Cryo-EM structure of Long-wave-sensitive opsin 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Long-wave-sensitive opsin 1 | polymer | 364 | 40606.2 | 1 | UniProt (P04000) Pfam (PF00001) | Homo sapiens (human) | Red cone photoreceptor pigment,Red-sensitive opsin,ROP |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40447.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (domestic cattle) | G gamma-I |
| 5 | E (S) | scFv Recombinant Human Monoclonal Antibody (scFv16) | polymer | 259 | 27563.8 | 1 | Homo sapiens (human) | ||
| 6 | F (R) | RETINAL | non-polymer | 284.4 | 1 | Chemie (RET) PubChem (23254473) PubChem (177675058) PubChem (5280490) PubChem (5381765) PubChem (1070) PubChem (87082476) PubChem (87110449) PubChem (87110609) PubChem (88398773) PubChem (88407543) PubChem (638015) PubChem (5353924) PubChem (6436079) PubChem (6436082) PubChem (134688327) PubChem (11426127) PubChem (12227253) PubChem (12227254) PubChem (12227256) PubChem (12227257) PubChem (12227258) PubChem (12227259) PubChem (12227269) PubChem (12227270) PubChem (12227271) PubChem (140510408) PubChem (145826762) PubChem (169423542) PubChem (172878320) |
Sequence modifications
R: 1 - 364 (UniProt: P04000)
A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Gln 129 | Glu 129 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | Ser 47 | engineered mutation |
| Thr 202 | Gly 202 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 153895.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 284.4 | |
| All* | Total formula weight | 154179.6 |
