8IU1
Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Galectin-3 | polymer | 146 | 16454.9 | 1 | UniProt (P16110) Pfam (PF00337) | Homo sapiens (human) | Gal-3,35 kDa lectin,Carbohydrate-binding protein 35,CBP 35,Galactose-specific lectin 3,IgE-binding protein,L-34 galactoside-binding lectin,Laminin-binding protein,Lectin L-29,Mac-2 antigen |
| 2 | B (A) | 2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid | non-polymer | 580.4 | 1 | Chemie (QB2) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 122 - 264 (UniProt: P16110)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| His 120 | - | expression tag |
| Met 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16454.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 604.7 | |
| All* | Total formula weight | 17059.6 |
