8ISQ
Crystal structure of extended-spectrum class A beta-lactamase, CESS-1 E166Q acylated by ampicillin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-lactamase | polymer | 269 | 28652.3 | 1 | UniProt (A0A126NGE0) | Stenotrophomonas sp. KCTC 12332 | CESS-1 |
| 2 | B (A) | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | non-polymer | 367.4 | 1 | Chemie (ZZ7) | |||
| 3 | C (A) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A: 26 - 291 (UniProt: A0A126NGE0)
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | cloning artifact |
| Ser 23 | - | cloning artifact |
| His 24 | - | cloning artifact |
| Met 25 | - | cloning artifact |
| Gln 166 | Glu 173 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28652.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 668.8 | |
| All* | Total formula weight | 29321.0 |
