8IRV

Dopamine Receptor D5R-Gs-Rotigotine complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	360	41748.3	1	Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092)	Homo sapiens
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	348	38146.7	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (human)
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (R)	Soluble cytochrome b562,D(1B) dopamine receptor	polymer	617	68847.3	1	UniProt (P0ABE7) UniProt (P21918) Pfam (PF07361) Pfam (PF00001)	Escherichia coli	Cytochrome b-562,D(5) dopamine receptor,D1beta dopamine receptor,Dopamine D5 receptor
5	E (R)	Rotigotine	non-polymer		315.5	1	Chemie (R5F)
6	F, G, H, I, J... (R)	CHOLESTEROL	non-polymer		386.7	10	Chemie (CLR)
7	P (R)	PALMITIC ACID	non-polymer		256.4	1	Chemie (PLM)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -4	-	initiating methionine
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Gly 341	-	expression tag
Ser 342	-	expression tag
Ser 343	-	expression tag

R: -116 - -12 (UniProt: P0ABE7)

PDB	External Database	Details
Asp -139	-	expression tag
Tyr -138	-	expression tag
Lys -137	-	expression tag
Asp -136	-	expression tag
Asp -135	-	expression tag
Asp -134	-	expression tag
Asp -133	-	expression tag
Ala -132	-	expression tag
Lys -131	-	expression tag
Leu -130	-	expression tag
Gln -129	-	expression tag
Thr -128	-	expression tag
Met -127	-	expression tag
His -126	-	expression tag
His -125	-	expression tag
His -124	-	expression tag
His -123	-	expression tag
His -122	-	expression tag
His -121	-	expression tag
His -120	-	expression tag
His -119	-	expression tag
His -118	-	expression tag
His -117	-	expression tag
Trp -110	Met 29	conflict
Ile -15	His 124	conflict
Leu -11	-	linker
Ala -10	-	linker
Ser -9	-	linker
Glu -8	-	linker
Asn -7	-	linker
Leu -6	-	linker
Tyr -5	-	linker
Phe -4	-	linker
Gln -3	-	linker
Gly -2	-	linker
Gly -1	-	linker
Thr 0	-	linker

R: 1 - 477 (UniProt: P21918)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	156603.4
Non-Polymers*	Number of molecules	12
	Total formula weight	4438.4
All*	Total formula weight	161041.9

*Water molecules are not included.