8INZ

Cryo-EM structure of human HCN3 channel in apo state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, A, B, D)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3	polymer	774	86142.9	4	UniProt (Q9P1Z3) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027)	Homo sapiens (human)
2	E, F, G, H (C, A, B, D)	4-[[(2~{S},4~{a}~{R},6~{S},8~{a}~{S})-6-[(4~{S},5~{R})-4-[(2~{S})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid	non-polymer		492.8	4	Chemie (VX9)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	344571.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1971.1
All*	Total formula weight	346542.8

*Water molecules are not included.