8IK3

Structure of Stimulator of interferon genes/ligand complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Stimulator of interferon genes protein,Immune protein Tsi3	polymer	521	58153.0	8	UniProt (Q86WV6) UniProt (Q9HYC4) Pfam (PF23417) Pfam (PF15009) Pfam (PF22211)	Homo sapiens (human)	hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173,Anti-toxin protein Tsi3
2	I, J, K, L (B, D, G, F)	cGAMP	non-polymer		674.4	4	Chemie (1SY)

Sequence modifications

A, B, C, D, E, G, F, H: 1 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Arg 232	His 232	conflict
Leu 380	-	linker
Glu 381	-	linker
Val 382	-	linker
Leu 383	-	linker
Phe 384	-	linker
Gln 385	-	linker
Gly 386	-	linker
Pro 387	-	linker

A, B, C, D, E, G, F, H: 388 - 511 (UniProt: Q9HYC4)

PDB	External Database	Details
Ser 512	-	expression tag
Ser 513	-	expression tag
His 514	-	expression tag
His 515	-	expression tag
His 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	465224.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2697.6
All*	Total formula weight	467921.6

*Water molecules are not included.