8IJD
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hydroxycarboxylic acid receptor 2 | polymer | 294 | 34252.0 | 1 | UniProt (Q8TDS4) Pfam (PF00001) In PDB | Homo sapiens (human) | G-protein coupled receptor 109A,G-protein coupled receptor HM74A,Niacin receptor 1,Nicotinic acid receptor |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 337 | 37069.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40153.7 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 56 | 6218.2 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | S | scFv16 | polymer | 248 | 26424.4 | 1 | Homo sapiens | ||
6 | A | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid | non-polymer | 386.4 | 1 | Chemie (FI7) |
Sequence modifications
C: 4 - 354 (UniProt: P63096)
PDB | External Database | Details |
---|---|---|
Ala 203 | Gly 203 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 144117.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 386.4 | |
All* | Total formula weight | 144504.1 |