8IJB
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hydroxycarboxylic acid receptor 2 | polymer | 294 | 34252.0 | 1 | UniProt (Q8TDS4) Pfam (PF00001) In PDB | Homo sapiens (human) | G-protein coupled receptor 109A,G-protein coupled receptor HM74A,Niacin receptor 1,Nicotinic acid receptor |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 337 | 37069.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40153.7 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 56 | 6218.2 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 5 | S | scFv16 | polymer | 248 | 26424.4 | 1 | Homo sapiens (human) | ||
| 6 | A | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid | non-polymer | 155.1 | 1 | Chemie (OJX) |
Sequence modifications
C: 4 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 144117.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 155.1 | |
| All* | Total formula weight | 144272.9 |
