8II2

Crystal structure of V30M-TTR in complex with BBM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	159	17342.6	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (human)	ATTR,Prealbumin,TBPA
2	A, B	[3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone	non-polymer		424.1	2	Chemie (R75)
3	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
4		water	water		18.0	104	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	initiating methionine
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Met 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34685.2
Non-Polymers*	Number of molecules	3
	Total formula weight	888.2
All*	Total formula weight	35573.4

*Water molecules are not included.