8IG8
Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with GC376
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | 3C-like proteinase nsp5 | polymer | 303 | 33523.3 | 2 | UniProt (P0DTC1) Pfam (PF05409) In PDB | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | A, B | N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide | non-polymer | 405.5 | 2 | Chemie (UED) | |||
| 3 | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 304 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Phe 46 | Ser 3309 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67046.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 811.0 | |
| All* | Total formula weight | 67857.5 |
