8IFZ

Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 spike protein receptor-binding domain in complex with white-tailed deer ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Spike protein S1	polymer	238	26933.8	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
2	B (A)	Angiotensin-converting enzyme	polymer	661	76530.5	1	UniProt (A0A6J0Z472)	Odocoileus virginianus (white-tailed deer)
3	C, D, E, F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
4	H (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

B: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Met 304	-	initiating methionine
Phe 305	-	expression tag
Val 306	-	expression tag
Phe 307	-	expression tag
Leu 308	-	expression tag
Val 309	-	expression tag
Leu 310	-	expression tag
Leu 311	-	expression tag
Pro 312	-	expression tag
Leu 313	-	expression tag
Val 314	-	expression tag
Ser 315	-	expression tag
Ser 316	-	expression tag
Gln 317	-	expression tag
Cys 318	-	expression tag
Asp 339	Gly 339	variant
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Arg 452	Leu 452	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Val 486	Phe 486	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	103464.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1171.4
All*	Total formula weight	104635.7

*Water molecules are not included.