8IBV
Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Soluble cytochrome b562,Motilin receptor,Soluble cytochrome b562, motilin receptor | polymer | 741 | 81667.0 | 1 | UniProt (P0ABE7) UniProt (O43193) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,G-protein coupled receptor 38 |
2 | C | Motilin | polymer | 22 | 2703.1 | 1 | UniProt (P12872) Pfam (PF04644) In PDB | Homo sapiens | |
3 | A | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41724.4 | 1 | Homo sapiens (human) | ||
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
5 | E | Scfv16 | polymer | 247 | 26277.3 | 1 | Homo sapiens (human) | ||
6 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
Sequence modifications
R: -116 - -12 (UniProt: P0ABE7)
R: 1 - 412 (UniProt: O43193)
R: 413 - 585 (PDB: 8IBV)
B: 7 - 345 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -155 | - | initiating methionine |
Lys -154 | - | expression tag |
Thr -153 | - | expression tag |
Ile -152 | - | expression tag |
Ile -151 | - | expression tag |
Ala -150 | - | expression tag |
Leu -149 | - | expression tag |
Ser -148 | - | expression tag |
Tyr -147 | - | expression tag |
Ile -146 | - | expression tag |
Phe -145 | - | expression tag |
Cys -144 | - | expression tag |
Leu -143 | - | expression tag |
Val -142 | - | expression tag |
Phe -141 | - | expression tag |
Ala -140 | - | expression tag |
Asp -139 | - | expression tag |
Tyr -138 | - | expression tag |
Lys -137 | - | expression tag |
Asp -136 | - | expression tag |
Asp -135 | - | expression tag |
Asp -134 | - | expression tag |
Asp -133 | - | expression tag |
Ala -132 | - | expression tag |
Lys -131 | - | expression tag |
Leu -130 | - | expression tag |
Gln -129 | - | expression tag |
Thr -128 | - | expression tag |
Met -127 | - | expression tag |
His -126 | - | expression tag |
His -125 | - | expression tag |
His -124 | - | expression tag |
His -123 | - | expression tag |
His -122 | - | expression tag |
His -121 | - | expression tag |
His -120 | - | expression tag |
His -119 | - | expression tag |
His -118 | - | expression tag |
His -117 | - | expression tag |
Trp -110 | Met 29 | conflict |
Ile -15 | His 124 | conflict |
Leu -11 | - | linker |
Ala -10 | - | linker |
Ser -9 | - | linker |
Glu -8 | - | linker |
Asn -7 | - | linker |
Leu -6 | - | linker |
Tyr -5 | - | linker |
Phe -4 | - | linker |
Gln -3 | - | linker |
Gly -2 | - | linker |
Gly -1 | - | linker |
Thr 0 | - | linker |
R: 413 - 585 (PDB: 8IBV)
B: 7 - 345 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Gly 2 | - | expression tag |
Ser 3 | - | expression tag |
Leu 4 | - | expression tag |
Leu 5 | - | expression tag |
Gln 6 | - | expression tag |
Gly 346 | - | expression tag |
Ser 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Gly 354 | - | expression tag |
Gly 355 | - | expression tag |
Gly 356 | - | expression tag |
Gly 357 | - | expression tag |
Ser 358 | - | expression tag |
Ser 359 | - | expression tag |
Gly 360 | - | expression tag |
Val 361 | - | expression tag |
Ser 362 | - | expression tag |
Gly 363 | - | expression tag |
Trp 364 | - | expression tag |
Arg 365 | - | expression tag |
Leu 366 | - | expression tag |
Phe 367 | - | expression tag |
Lys 368 | - | expression tag |
Lys 369 | - | expression tag |
Ile 370 | - | expression tag |
Ser 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 200328.7 | |
All* | Total formula weight | 200328.7 |