8IA8
Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG | polymer | 15 | 1825.2 | 1 | Homo sapiens | ||
| 2 | B (A) | C3a anaphylatoxin chemotactic receptor | polymer | 482 | 53906.9 | 1 | UniProt (Q16581) Pfam (PF00001) | Homo sapiens (human) | C3AR,C3a-R |
| 3 | C (C) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40153.7 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1,G protein beta subunit |
| 5 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (S) | scFv16 | polymer | 247 | 26337.3 | 1 | Vicugna pacos |
Sequence modifications
C: 4 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 167501.1 | |
| All* | Total formula weight | 167501.1 |
