8I8S
Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGMP and Mn2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 156 | 18043.6 | 2 | UniProt (P36639) Pfam (PF00293) | Homo sapiens (human) | MutT homologue-1,2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
| 2 | C, G (A, B) | 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE | non-polymer | 363.2 | 2 | Chemie (8OG) | |||
| 3 | D, E, F, H, I... (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 387 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Lys 2 | Gly 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36087.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1056.1 | |
| All* | Total formula weight | 37143.3 |
