8I7V
Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Human hydroxycarboxylic acid receptor 2,Hydroxycarboxylic acid receptor 2,Hydroxycarboxylic acid receptor 2 | polymer | 476 | 54320.3 | 1 | UniProt (Q8TDS4) Pfam (PF07361) Pfam (PF00001) UniProt (by SIFTS) (P0ABE7) | Homo sapiens | G-protein coupled receptor 109A,G-protein coupled receptor HM74A,Niacin receptor 1,Nicotinic acid receptor |
| 2 | B (B) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 80 | 8506.8 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | scFv16 | polymer | 257 | 27409.6 | 1 | Mus musculus | ||
| 6 | F (A) | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid | non-polymer | 155.1 | 1 | Chemie (OJX) |
Sequence modifications
A: -112 - 0 (PDB: 8I7V)
A: 1 - 363 (UniProt: Q8TDS4)
C: 2 - 340 (UniProt: P62873)
D: 1 - 71 (UniProt: P59768)
A: 1 - 363 (UniProt: Q8TDS4)
C: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 72 | - | expression tag |
| Ser 73 | - | expression tag |
| Ala 74 | - | expression tag |
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| Ala 77 | - | expression tag |
| Gly 78 | - | expression tag |
| Ser 79 | - | expression tag |
| Ala 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 168379.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 155.1 | |
| All* | Total formula weight | 168535.0 |
