8I2N
The RIPK1 kinase domain in complex with QY7-2B compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 294 | 33468.7 | 2 | UniProt (Q13546) Pfam (PF07714) | Homo sapiens (human) | Cell death protein RIP,Receptor-interacting protein 1,RIP-1 |
| 2 | C, D (A, B) | ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide | non-polymer | 478.5 | 2 | Chemie (O4U) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Ala 34 | Cys 34 | engineered mutation |
| Ala 127 | Cys 127 | engineered mutation |
| Ala 233 | Cys 233 | engineered mutation |
| Ala 240 | Cys 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66937.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 957.1 | |
| All* | Total formula weight | 67894.6 |
