8I2C

E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tryptophan--tRNA ligase	polymer	340	38373.7	2	UniProt (P00954) Pfam (PF00579)	Escherichia coli K-12	Tryptophanyl-tRNA synthetase,TrpRS
2	C (A)	4-methoxyaniline	non-polymer		123.2	1	Chemie (O8U)
3	D (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	E (B)	TRYPTOPHANYL-5'AMP	non-polymer		533.4	1	Chemie (TYM)
5	F (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	G, H (A, B)	water	water		18.0	213	Chemie (HOH)

Sequence modifications

A, B: 1 - 333 (UniProt: P00954)

PDB	External Database	Details
Arg 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76747.5
Non-Polymers*	Number of molecules	4
	Total formula weight	814.7
All*	Total formula weight	77562.2

*Water molecules are not included.