8I2B
Human SIRT6 in complex with inhibitor 7702
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | NAD-dependent protein deacylase sirtuin-6 | polymer | 290 | 32263.1 | 2 | UniProt (Q8N6T7) Pfam (PF02146) In PDB | Homo sapiens (human) | NAD-dependent protein deacetylase sirtuin-6,Protein mono-ADP-ribosyltransferase sirtuin-6,Regulatory protein SIR2 homolog 6,hSIRT6,SIR2-like protein 6 |
| 2 | A, B | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) | |||
| 3 | A, B | N1-[[4-(4-aminophenyl)sulfanyl-3-(trifluoromethyl)phenyl]methoxy]benzene-1,4-dicarboxamide | non-polymer | 461.5 | 2 | Chemie (O5L) | |||
| 4 | A, B | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) | |||
| 5 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B: 13 - 298 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Ala 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Thr 12 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64526.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3235.4 | |
| All* | Total formula weight | 67761.6 |
