8I2B
Human SIRT6 in complex with inhibitor 7702
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacylase sirtuin-6 | polymer | 290 | 32263.1 | 2 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (human) | NAD-dependent protein deacetylase sirtuin-6,Protein mono-ADP-ribosyltransferase sirtuin-6,Regulatory protein SIR2 homolog 6,hSIRT6,SIR2-like protein 6 |
| 2 | C, G, H (A, B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) PubChem (8200) | |||
| 3 | D, I (A, B) | N1-[[4-(4-aminophenyl)sulfanyl-3-(trifluoromethyl)phenyl]methoxy]benzene-1,4-dicarboxamide | non-polymer | 461.5 | 2 | Chemie (O5L) PubChem (169503050) | |||
| 4 | E, J (A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) PubChem (192) PubChem (25113622) PubChem (25113623) PubChem (445794) PubChem (44415180) PubChem (447048) PubChem (44144391) PubChem (51051599) PubChem (33576) PubChem (89379870) PubChem (91746164) PubChem (447165) PubChem (448826) PubChem (10437766) PubChem (9548001) PubChem (9547960) PubChem (122606931) PubChem (122609061) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (174159053) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949) | |||
| 5 | F, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | L, M, N, O, P (B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | Q, R (A, B) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B: 13 - 298 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Ala 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Thr 12 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64526.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3235.4 | |
| All* | Total formula weight | 67761.6 |
