8I1C
Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP at pH 9.1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 156 | 18043.6 | 2 | UniProt (P36639) Pfam (PF00293) | Homo sapiens (human) | MutT homologue-1,2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
| 2 | C, D, E, F (A, B) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 3 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 376 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Lys 2 | Gly 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36087.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 184.1 | |
| All* | Total formula weight | 36271.2 |
