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8I0S

The cryo-EM structure of human Bact-II complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Pre-mRNA-processing-splicing factor 8polymer2335273974.31UniProt (Q6P2Q9)Homo sapiens (human)220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220
2B
(B)
U5 snRNApolymer11737254.91GenBank (20330981)Homo sapiens (human)
3C
(C)
116 kDa U5 small nuclear ribonucleoprotein componentpolymer972109560.61UniProt (Q15029)Homo sapiens (human)SNU114,Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa
4D
(D)
U5 small nuclear ribonucleoprotein 200 kDa helicasepolymer2136244823.41UniProt (O75643)Homo sapiens (human)Activating signal cointegrator 1 complex subunit 3-like 1,BRR2 homolog,U5 snRNP-specific 200 kDa protein,U5-200KD
5E
(E)
U5 small nuclear ribonucleoprotein 40 kDa proteinpolymer35739359.51UniProt (Q96DI7)Homo sapiens (human)U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57
6F
(F)
U6 snRNApolymer10734404.41Homo sapiens
7G
(G)
pre-mRNApolymer22070435.41unidentified adenovirus
8H
(H)
U2 snRNApolymer18860186.41GenBank (340097)Homo sapiens (human)
9I
(I)
Pre-mRNA-splicing factor SYF1polymer855100148.71UniProt (Q9HCS7)Homo sapiens (human)Protein HCNP,XPA-binding protein 2
10J
(J)
Crooked neck-like protein 1polymer848100610.01UniProt (Q9BZJ0)Homo sapiens (human)Crooked neck homolog,hCrn
11K
(K)
RING finger protein 113Apolymer34338847.21UniProt (O15541)Homo sapiens (human)Zinc finger protein 183
12L
(L)
Cell division cycle 5-like proteinpolymer80292406.91UniProt (Q99459)Homo sapiens (human)Cdc5-like protein,Pombe cdc5-related protein
13M
(N)
Protein BUD31 homologpolymer14417032.81UniProt (P41223)Homo sapiens (human)Protein EDG-2,Protein G10 homolog
14N
(O)
Pre-mRNA-splicing factor RBM22polymer42046959.61UniProt (Q9NW64)Homo sapiens (human)RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16
15O
(P)
Spliceosome-associated protein CWC15 homologpolymer22926674.41UniProt (Q9P013)Homo sapiens (human)
16P
(Q)
RNA helicase aquariuspolymer1485171502.51UniProt (O60306)Homo sapiens (human)Intron-binding protein of 160 kDa,IBP160
17Q
(R)
SNW domain-containing protein 1polymer53661690.71UniProt (Q13573)Homo sapiens (human)Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein
18R
(S)
Peptidyl-prolyl cis-trans isomerase-like 1polymer16618257.81UniProt (Q9Y3C6)Homo sapiens (human)PPIase,Rotamase PPIL1
19S
(T)
Pleiotropic regulator 1polymer51457280.81UniProt (O43660)Homo sapiens (human)
20T
(U)
Serine/arginine repetitive matrix protein 2polymer2752300255.31UniProt (Q9UQ35)Homo sapiens (human)300 kDa nuclear matrix antigen,Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,Ser/Arg-related nuclear matrix protein of 300 kDa,Splicing coactivator subunit SRm300,Tax-responsive enhancer element-binding protein 803,TaxREB803
21U
(V)
Pre-mRNA-splicing factor CWC22 homologpolymer908105646.61UniProt (Q9HCG8)Homo sapiens (human)Nucampholin homolog,fSAPb
22V
(X)
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16polymer1041119443.61UniProt (O60231)Homo sapiens (human)ATP-dependent RNA helicase #3,DEAH-box protein 16
23W
(Y)
Peptidyl-prolyl cis-trans isomerase-like 4polymer49257324.21UniProt (Q8WUA2)Homo sapiens (human)PPIase,Cyclophilin-like protein PPIL4,Rotamase PPIL4
24X
(1)
Splicing factor 3B subunit 1polymer1304146024.91UniProt (O75533)Homo sapiens (human)Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155,Spliceosome-associated protein 155,SAP 155
25Y
(3)
Splicing factor 3B subunit 3polymer1217135718.81UniProt (Q15393)Homo sapiens (human)Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130
26Z
(p)
U2 small nuclear ribonucleoprotein B''polymer22525524.41UniProt (P08579)Homo sapiens (human)U2 snRNP B''
27AA
(w)
Splicing factor 3A subunit 3polymer50158934.81UniProt (Q12874)Homo sapiens (human)SF3a60,Spliceosome-associated protein 61,SAP 61
28BA
(2)
Splicing factor 3B subunit 2polymer895100377.81UniProt (Q13435)Homo sapiens (human)Pre-mRNA-splicing factor SF3b 145 kDa subunit,SF3b145,Spliceosome-associated protein 145,SAP 145
29CA
(4)
Splicing factor 3B subunit 4polymer42444436.61UniProt (Q15427)Homo sapiens (human)Pre-mRNA-splicing factor SF3b 49 kDa subunit,Spliceosome-associated protein 49,SAP 49
30DA
(7)
PHD finger-like domain-containing protein 5Apolymer11012427.51UniProt (Q7RTV0)Homo sapiens (human)PHD finger-like domain protein 5A,Splicing factor 3B-associated 14 kDa protein,SF3b14b
31EA
(5)
Splicing factor 3B subunit 5polymer8610149.41UniProt (Q9BWJ5)Homo sapiens (human)SF3b5,Pre-mRNA-splicing factor SF3b 10 kDa subunit
32FA
(y)
Peptidyl-prolyl cis-trans isomerase Epolymer30133475.81UniProt (Q9UNP9)Homo sapiens (human)PPIase E,Cyclophilin E,Cyclophilin-33,Rotamase E
33GA
(v)
Splicing factor 3A subunit 2polymer46449327.41UniProt (Q15428)Homo sapiens (human)SF3a66,Spliceosome-associated protein 62,SAP 62
34HA
(u)
Splicing factor 3A subunit 1polymer79388991.11UniProt (Q15459)Homo sapiens (human)SF3a120,Spliceosome-associated protein 114,SAP 114
35IA
(9)
RING-type E3 ubiquitin-protein ligase PPIL2polymer52058910.41UniProt (Q13356)Homo sapiens (human)Probable inactive peptidyl-prolyl cis-trans isomerase-like 2,PPIase,Rotamase PPIL2
36JA, TA
(a, m)
Small nuclear ribonucleoprotein-associated proteins B and B'polymer24024642.12UniProt (P14678)Homo sapiens (human)SmB,snRNP-B,Sm protein B/B',SmB/B'
37KA, XA
(b, n)
Small nuclear ribonucleoprotein Sm D1polymer11913310.72UniProt (P62314)Homo sapiens (human)Sm-D1,Sm-D autoantigen,snRNP core protein D1
38LA, RA
(c, h)
Small nuclear ribonucleoprotein Sm D2polymer11813551.92UniProt (P62316)Homo sapiens (human)Sm-D2,snRNP core protein D2
39MA, SA
(d, i)
Small nuclear ribonucleoprotein Fpolymer869734.22UniProt (P62306)Homo sapiens (human)snRNP-F,Sm protein F,SmF
40NA, WA
(e, j)
Small nuclear ribonucleoprotein Epolymer9210817.62UniProt (P62304)Homo sapiens (human)snRNP-E,Sm protein E,SmE
41OA, VA
(f, k)
Small nuclear ribonucleoprotein Gpolymer768508.12UniProt (P62308)Homo sapiens (human)snRNP-G,Sm protein G,SmG
42PA, UA
(g, l)
Small nuclear ribonucleoprotein Sm D3polymer12613940.32UniProt (P62318)Homo sapiens (human)Sm-D3,snRNP core protein D3
43QA
(o)
U2 small nuclear ribonucleoprotein A'polymer25528456.61UniProt (P09661)Homo sapiens (human)U2-A',U2 snRNP A'
44YA
(A)
INOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
45ZA
(C)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
46AB, BB, CB, DB, EB...
(C, F)
MAGNESIUM IONnon-polymer24.37Chemie (MG)
47HB, IB, JB, KB, LB...
(K, N, 7)
ZINC IONnon-polymer65.47Chemie (ZN)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains50
Total formula weight3165845.2
Non-Polymers*Number of molecules16
Total formula weight1811.2
All*Total formula weight3167656.4
*Water molecules are not included.

238582

PDB entries from 2025-07-09

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