8I0O

Crystal structure of Transthyretin variant A97S in monomeric form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transthyretin	polymer	127	13795.4	4	UniProt (P02766) Pfam (PF00576)	Homo sapiens (human)	ATTR,Prealbumin,TBPA
2	E, F (A, D)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
3	G, H, I, J (A, B, C, D)	water	water		18.0	418	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 127 (UniProt: P02766)

PDB	External Database	Details
Met 87	Phe 107	engineered mutation
Ser 97	Ala 117	variant
Met 110	Leu 130	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55181.7
Non-Polymers*	Number of molecules	2
	Total formula weight	236.3
All*	Total formula weight	55418.0

*Water molecules are not included.