8HV8
Crystal structure of EGFR_TMX in complex with covalently bound fragment 10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 331 | 37533.3 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL | non-polymer | 398.5 | 1 | Chemie (PE5) | |||
| 3 | C (A) | ~{N}-pyrazolo[1,5-a]pyridin-2-ylprop-2-enamide | non-polymer | 187.2 | 1 | Chemie (N99) | |||
| 4 | D (A) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
| Met 790 | Thr 790 | variant |
| Ser 797 | Cys 797 | engineered mutation |
| Arg 858 | Leu 858 | variant |
| Ala 865 | Glu 865 | engineered mutation |
| Ala 866 | Glu 866 | engineered mutation |
| Ala 867 | Lys 867 | engineered mutation |
| Asn 1023 | - | expression tag |
| Ser 1024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37533.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 585.7 | |
| All* | Total formula weight | 38119.0 |
