8HV6
Crystal structure of EGFR_TMX in complex with covalently bound fragment 8
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 331 | 37533.3 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL | non-polymer | 398.5 | 1 | Chemie (PE5) | |||
3 | A | ~{N}-quinolin-7-ylprop-2-enamide | non-polymer | 198.2 | 1 | Chemie (N86) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 694 | - | expression tag |
Met 790 | Thr 790 | variant |
Ser 797 | Cys 797 | variant |
Arg 858 | Leu 858 | variant |
Ala 865 | Glu 865 | engineered mutation |
Ala 866 | Glu 866 | engineered mutation |
Ala 867 | Lys 867 | engineered mutation |
Asn 1023 | - | expression tag |
Ser 1024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37533.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 674.8 | |
All* | Total formula weight | 38208.2 |