8HQN
Activation mechanism of GPR132 by 9(S)-HODE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39489.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
2 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
3 | H | scFv16 | polymer | 250 | 26610.6 | 1 | Mus musculus | ||
4 | R | Soluble cytochrome b562,Probable G-protein coupled receptor 132 | polymer | 510 | 57125.3 | 1 | UniProt (P0ABE7) UniProt (Q9UNW8) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,G2 accumulation protein |
5 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
6 | R | (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid | non-polymer | 296.4 | 1 | Chemie (9HO) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -105 - 0 (UniProt: P0ABE7)
R: 1 - 380 (UniProt: Q9UNW8)
A: 1 - 354 (UniProt: P63096)
PDB | External Database | Details |
---|---|---|
Met -17 | - | initiating methionine |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -129 | - | initiating methionine |
Lys -128 | - | expression tag |
Thr -127 | - | expression tag |
Ile -126 | - | expression tag |
Ile -125 | - | expression tag |
Ala -124 | - | expression tag |
Leu -123 | - | expression tag |
Ser -122 | - | expression tag |
Tyr -121 | - | expression tag |
Ile -120 | - | expression tag |
Phe -119 | - | expression tag |
Cys -118 | - | expression tag |
Leu -117 | - | expression tag |
Val -116 | - | expression tag |
Phe -115 | - | expression tag |
Ala -114 | - | expression tag |
Asp -113 | - | expression tag |
Tyr -112 | - | expression tag |
Lys -111 | - | expression tag |
Asp -110 | - | expression tag |
Asp -109 | - | expression tag |
Asp -108 | - | expression tag |
Asp -107 | - | expression tag |
Lys -106 | - | expression tag |
Trp -99 | Met 29 | conflict |
Ile -4 | His 124 | conflict |
Leu 0 | Arg 128 | conflict |
A: 1 - 354 (UniProt: P63096)
PDB | External Database | Details |
---|---|---|
Ala 203 | Gly 203 | conflict |
Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 170045.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 296.4 | |
All* | Total formula weight | 170341.9 |