8HPU

Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Spike protein S2'	polymer	194	21905.7	1	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
2	H	fab L4.65	polymer	231	24953.9	1		Homo sapiens
3	L	fab L4.65	polymer	215	23556.1	1		Homo sapiens
4	M	fab L5.34	polymer	224	23592.4	1		Homo sapiens
5	N	fab L5.34	polymer	216	23379.9	1		Homo sapiens
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 348 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Asp 353	Gly 339	variant
Phe 385	Ser 371	variant
Pro 387	Ser 373	variant
Phe 389	Ser 375	variant
Ala 390	Thr 376	variant
Asn 419	Asp 405	variant
Ser 422	Arg 408	variant
Asn 431	Lys 417	variant
Lys 454	Asn 440	variant
Arg 466	Leu 452	variant
Asn 491	Ser 477	variant
Lys 492	Thr 478	variant
Ala 498	Glu 484	variant
Val 500	Phe 486	variant
Arg 512	Gln 498	variant
Tyr 515	Asn 501	variant
His 519	Tyr 505	variant

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	117388.0
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	117609.3

*Water molecules are not included.