8HPA
Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase | polymer | 1029 | 120041.2 | 1 | UniProt (Q5IXW8) Pfam (PF08452) Pfam (PF03104) Pfam (PF08408) Pfam (PF00136) UniProt (by SIFTS) (A0A7H0DN44) | Monkeypox virus | |
| 2 | B (C) | DNA polymerase processivity factor component A20 | polymer | 426 | 49203.9 | 1 | UniProt (Q5IXP2) Pfam (PF05941) UniProt (by SIFTS) (A0A7H0DNC0) | Monkeypox virus | |
| 3 | C (B) | E4R | polymer | 241 | 27883.7 | 1 | UniProt (Q5IXS4) UniProt (by SIFTS) (M1LL92) | Monkeypox virus | |
| 4 | D (E) | DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3') | polymer | 26 | 8148.3 | 1 | DNA molecule | ||
| 5 | E (D) | DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3') | polymer | 23 | 6921.5 | 1 | DNA molecule |
Sequence modifications
A: 1 - 1006 (UniProt: Q5IXW8)
B: 1 - 218 (UniProt: Q5IXS4)
| PDB | External Database | Details |
|---|---|---|
| Met -22 | - | initiating methionine |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Tyr -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Ile -10 | - | expression tag |
| Pro -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Phe 108 | Leu 108 | engineered mutation |
| Leu 411 | Trp 411 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -22 | - | initiating methionine |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Tyr -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Ile -12 | - | expression tag |
| Pro -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 212198.5 | |
| All* | Total formula weight | 212198.5 |
