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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HNK

CXCR3-DNGi complex activated by CXCL11

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AGuanine nucleotide-binding protein G(i) subunit alpha-1polymer35440445.11UniProt (P63096)
Pfam (PF00503)
In PDB		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2BGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer38442005.91UniProt (P62873)
Pfam (PF00400)
In PDB		Homo sapiens (human)Transducin beta chain 1
3GGuanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)
In PDB		Homo sapiens (human)G gamma-I
4RSoluble cytochrome b562,C-X-C chemokine receptor type 3,Oplophorus-luciferin 2-monooxygenase catalytic subunitpolymer65772918.01UniProt (P0ABE7)
UniProt (P49682)
UniProt (Q9GV45)
Pfam (PF07361)
Pfam (PF00001)
In PDB		Escherichia coliCytochrome b-562,CXC-R3,CXCR-3,CKR-L2,G protein-coupled receptor 9,Interferon-inducible protein 10 receptor,IP-10 receptor,19kOLase
5LC-X-C motif chemokine 11polymer10411764.11UniProt (O14625)
Pfam (PF00048)
In PDB		Homo sapiens (human)Beta-R1,H174,Interferon gamma-inducible protein 9,IP-9,Interferon-inducible T-cell alpha chemoattractant,I-TAC,Small-inducible cytokine B11
6Ssingle-chain variable fragment scFv16polymer25927784.91Homo sapiens (human)
7RCHOLESTEROLnon-polymer386.72Chemie (CLR)
Sequence modifications
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Ala 203Gly 203conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ala 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Ala 345-expression tag
Ser 346-expression tag
Gly 347-expression tag
Ala 348-expression tag
Ser 349-expression tag
Gly 350-expression tag
Ala 351-expression tag
Ser 352-expression tag
Val 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Trp 356-expression tag
Arg 357-expression tag
Leu 358-expression tag
Phe 359-expression tag
Lys 360-expression tag
Lys 361-expression tag
Ile 362-expression tag
Ser 363-expression tag
R: -111 - -7 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Met -137-initiating methionine
Lys -136-expression tag
Thr -135-expression tag
Ile -134-expression tag
Ile -133-expression tag
Ala -132-expression tag
Leu -131-expression tag
Ser -130-expression tag
Tyr -129-expression tag
Ile -128-expression tag
Phe -127-expression tag
Cys -126-expression tag
Leu -125-expression tag
Val -124-expression tag
Phe -123-expression tag
Ala -122-expression tag
Asp -121-expression tag
Tyr -120-expression tag
Lys -119-expression tag
Asp -118-expression tag
Asp -117-expression tag
Asp -116-expression tag
Asp -115-expression tag
Lys -114-expression tag
Gly -113-expression tag
Ser -112-expression tag
Trp -105Met 29conflict
Ile -10His 124conflict
Leu -6-linker
Leu -5-linker
Val -4-linker
Pro -3-linker
Arg -2-linker
Gly -1-linker
Ser 0-linker
R: 1 - 361 (UniProt: P49682)
R: 362 - 519 (UniProt: Q9GV45)
PDBExternal DatabaseDetails
Val 362Thr 27conflict
Glu 366Ala 31conflict
Glu 373Gln 38conflict
Ala 377Gly 42conflict
Leu 380Gln 45conflict
Val 389Leu 54conflict
Leu 393Phe 58conflict
Asn 395Ala 60conflict
Ala 397Gly 62conflict
Arg 405Lys 70conflict
Ile 406Val 71conflict
Arg 408Leu 73conflict
Ala 413Gly 78conflict
Ile 416Ala 81conflict
Ala 429Gly 94conflict
Asp 430Phe 95conflict
Ala 433Gly 98conflict
Gln 434Leu 99conflict
Glu 437Met 102conflict
Val 438Ile 103conflict
Val 452Ile 117conflict
Pro 455His 120conflict
Leu 469Ile 134conflict
Asn 470Asp 135conflict
Glu 477Pro 142conflict
Lys 486Gln 151conflict
Ile 500Tyr 165conflict
Thr 506Asn 171conflict
Met 511Leu 176conflict
Ser 519Gly 184conflict
L: -20 - 73 (UniProt: O14625)
PDBExternal DatabaseDetails
His 74-expression tag
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His 79-expression tag
His 80-expression tag
His 81-expression tag
His 82-expression tag
His 83-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight202779.1
Non-Polymers*Number of molecules2
Total formula weight773.3
All*Total formula weight203552.4
*Water molecules are not included.

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PDB entries from 2024-07-17

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