8HN1

Cryo-EM structure of AdTx1-alpha1AAR-Nb6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	Toxin AdTx1	polymer	71	7743.7	1	UniProt (P85092) Pfam (PF21947) In PDB	Dendroaspis angusticeps (eastern green mamba)	Rho-elapitoxin-Da1a,Rho-Da1a,Rho-EPTX-Da1a
2	A	Alpha-1A adrenergic receptor	polymer	346	38825.6	1	UniProt (P35348) Pfam (PF00001) In PDB	Homo sapiens (human)	Alpha-1A adrenoreceptor,Alpha-1A adrenoceptor,Alpha-1C adrenergic receptor,Alpha-adrenergic receptor 1c
3	D	Nb6	polymer	133	14730.3	1		Lama glama

Sequence modifications

C: 1 - 65 (UniProt: P85092)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

A: 1 - 371 (UniProt: P35348)

PDB	External Database	Details
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Ala 0	-	expression tag
Gln 7	Asn 7	conflict
Gln 13	Asn 13	conflict
Gln 22	Asn 22	conflict
Arg 113	Ser 113	conflict
Trp 115	Met 115	conflict
-	Glu 214	deletion
-	Ser 215	deletion
-	Arg 216	deletion
-	Gly 217	deletion
-	Leu 218	deletion
-	Lys 219	deletion
-	Ser 220	deletion
-	Gly 221	deletion
-	Leu 222	deletion
-	Lys 223	deletion
-	Thr 224	deletion
-	Asp 225	deletion
-	Lys 226	deletion
-	Ser 227	deletion
-	Asp 228	deletion
-	Ser 229	deletion
-	Glu 230	deletion
-	Gln 231	deletion
-	Val 232	deletion
-	Thr 233	deletion
-	Leu 234	deletion
-	Arg 235	deletion
-	Ile 236	deletion
-	His 237	deletion
-	Arg 238	deletion
-	Lys 239	deletion
-	Asn 240	deletion
-	Ala 241	deletion
-	Pro 242	deletion
-	Ala 243	deletion
-	Gly 244	deletion
-	Gly 245	deletion
-	Ser 246	deletion
-	Gly 247	deletion
-	Met 248	deletion
-	Ala 249	deletion
-	Ser 250	deletion
-	Ala 251	deletion
-	Lys 252	deletion
-	Thr 253	deletion
-	Lys 254	deletion
-	Thr 255	deletion
-	His 256	deletion
-	Phe 257	deletion
-	Ser 258	deletion
Ser 218	Lys 263	conflict
Gly 219	Phe 264	conflict
Asp 224	-	insertion
Arg 225	-	insertion
Asn 226	-	insertion
Leu 227	-	insertion
Arg 228	-	insertion
His 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	61299.6
All*	Total formula weight	61299.6

*Water molecules are not included.