8HMV
Structure of GPR21-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Probable G-protein coupled receptor 21 | polymer | 289 | 33183.9 | 1 | UniProt (Q99679) Pfam (PF00001) In PDB | Homo sapiens (Human) | |
| 2 | C | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 384 | 44747.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 57 | 6261.2 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
| 5 | N | Nanobody Nb35 | polymer | 126 | 13711.3 | 1 | synthetic construct |
Sequence modifications
C: 11 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Thr 205 | Ser 205 | conflict |
| Ala 226 | Gly 226 | engineered mutation |
| Ser 366 | Ala 366 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 135102.4 | |
| All* | Total formula weight | 135102.4 |
