8HMQ
Crystal Structure of PKM2 mutant P403A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Pyruvate kinase PKM | polymer | 551 | 60162.2 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (human) | Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Threonine-protein kinase PKM2,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,Tyrosine-protein kinase PKM2,p58 |
2 | A, B, C, D | OXALATE ION | non-polymer | 88.0 | 4 | Chemie (OXL) | |||
3 | D, A, B, C | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
4 | D, A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
5 | D, A, B, C | MAGNESIUM ION | non-polymer | 24.3 | 9 | Chemie (MG) | |||
6 | D, B, C | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 3 | Chemie (FBP) | |||
7 | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Ala 403 | Pro 403 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 240648.8 | |
Non-Polymers* | Number of molecules | 28 |
Total formula weight | 2546.2 | |
All* | Total formula weight | 243195.0 |