8HLP

Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Voltage-dependent L-type calcium channel subunit alpha	polymer	2173	243947.0	1	UniProt (A0A0A0MSA1) Pfam (PF00520) Pfam (PF16885) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) UniProt (by SIFTS) (Q13936) In PDB	Homo sapiens (human)
2	F	Voltage-dependent calcium channel subunit alpha-2/delta-1	polymer	1071	121197.4	1	UniProt (P54289) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) In PDB	Homo sapiens (human)	Voltage-gated calcium channel subunit alpha-2/delta-1
3	C	Isoform 2c of Voltage-dependent L-type calcium channel subunit beta-2	polymer	632	70952.7	1	UniProt (Q08289) Pfam (PF12052) Pfam (PF00625) In PDB	Homo sapiens (human)	CAB2,Calcium channel voltage-dependent subunit beta 2,Lambert-Eaton myasthenic syndrome antigen B,MYSB
4	A	HEXADECANE	non-polymer		226.4	9	Chemie (R16)
5	A	1,2-Distearoyl-sn-glycerophosphoethanolamine	non-polymer		748.1	2	Chemie (3PE)
6	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
7	F	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)

Sequence modifications

A: 1 - 2221 (UniProt: A0A0A0MSA1)

PDB	External Database	Details
Val 372	Met 372	conflict
Asn 373	Gln 373	conflict
Val 376	Met 376	conflict
Arg 378	Tyr 378	conflict
Asp 379	Glu 379	conflict
Trp 380	Leu 380	conflict
Ile 383	Val 383	conflict
Thr 387	Ser 387	conflict
Ile 389	Val 389	conflict
Ile 391	Phe 391	conflict
Leu 966	Ile 946	conflict
Ile 969	Ala 949	conflict
Val 1351	Thr 1303	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	436097.1
Non-Polymers*	Number of molecules	18
	Total formula weight	4720.3
All*	Total formula weight	440817.4

*Water molecules are not included.