8HLL
Crystal structure of p53/BCL2 fusion complex (complex 1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 196 | 22103.1 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | B (B) | Apoptosis regulator Bcl-2 | polymer | 173 | 19214.0 | 1 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
B: 10 - 77 (UniProt: P10415)
B: 92 - 203 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Gly 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Gln 9 | - | expression tag |
| Ser 20 | His 20 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 78 | - | linker |
| Glu 79 | - | linker |
| Asn 80 | - | linker |
| Arg 81 | - | linker |
| Thr 82 | - | linker |
| Glu 83 | - | linker |
| Ala 84 | - | linker |
| Pro 85 | - | linker |
| Glu 86 | - | linker |
| Gly 87 | - | linker |
| Thr 88 | - | linker |
| Glu 89 | - | linker |
| Ser 90 | - | linker |
| Glu 91 | - | linker |
| Gln 95 | Leu 95 | engineered mutation |
| Leu 106 | Arg 106 | engineered mutation |
| Gly 124 | Phe 124 | engineered mutation |
| Tyr 127 | Arg 127 | engineered mutation |
| Ala 128 | Gly 128 | engineered mutation |
| Ser 129 | Arg 129 | engineered mutation |
| Val 168 | Pro 168 | engineered mutation |
| Ala 175 | Leu 175 | engineered mutation |
| Ala 178 | Thr 178 | engineered mutation |
| Thr 179 | Glu 179 | engineered mutation |
| Asp 183 | Arg 183 | engineered mutation |
| Asn 204 | - | expression tag |
| Asn 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Gly 207 | - | expression tag |
| Gly 208 | - | expression tag |
| Gly 209 | - | expression tag |
| Ser 210 | - | expression tag |
| Leu 211 | - | expression tag |
| Val 212 | - | expression tag |
| Pro 213 | - | expression tag |
| Arg 214 | - | expression tag |
| Gly 215 | - | expression tag |
| Ser 216 | - | expression tag |
| Gly 217 | - | expression tag |
| Gly 218 | - | expression tag |
| Gly 219 | - | expression tag |
| Gly 220 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41317.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 41382.5 |
