8HGO
The EGF-bound EGFR/HER2 ectodomain complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Receptor tyrosine-protein kinase erbB-2 | polymer | 745 | 82149.8 | 1 | UniProt (P04626) Pfam (PF21314) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
2 | A | Epidermal growth factor receptor | polymer | 736 | 81075.3 | 1 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) Pfam (PF21314) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
3 | C | Epidermal growth factor | polymer | 57 | 6555.4 | 1 | UniProt (P01133) Pfam (PF00008) In PDB | Homo sapiens (human) | Urogastrone |
4 | D | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G50737AO) | |||
5 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
6 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
B: 1 - 693 (UniProt: P04626)
A: 1 - 683 (UniProt: P00533)
C: 1 - 53 (UniProt: P01133)
PDB | External Database | Details |
---|---|---|
Gly 694 | - | expression tag |
Gly 695 | - | expression tag |
Ser 696 | - | expression tag |
Glu 697 | - | expression tag |
Asn 698 | - | expression tag |
Leu 699 | - | expression tag |
Tyr 700 | - | expression tag |
Phe 701 | - | expression tag |
Gln 702 | - | expression tag |
Gly 703 | - | expression tag |
Gly 704 | - | expression tag |
Gly 705 | - | expression tag |
Ser 706 | - | expression tag |
Ala 707 | - | expression tag |
Gln 708 | - | expression tag |
Leu 709 | - | expression tag |
Glu 710 | - | expression tag |
Lys 711 | - | expression tag |
Glu 712 | - | expression tag |
Leu 713 | - | expression tag |
Gln 714 | - | expression tag |
Ala 715 | - | expression tag |
Leu 716 | - | expression tag |
Glu 717 | - | expression tag |
Lys 718 | - | expression tag |
Glu 719 | - | expression tag |
Asn 720 | - | expression tag |
Ala 721 | - | expression tag |
Gln 722 | - | expression tag |
Leu 723 | - | expression tag |
Glu 724 | - | expression tag |
Trp 725 | - | expression tag |
Glu 726 | - | expression tag |
Leu 727 | - | expression tag |
Gln 728 | - | expression tag |
Ala 729 | - | expression tag |
Leu 730 | - | expression tag |
Glu 731 | - | expression tag |
Lys 732 | - | expression tag |
Glu 733 | - | expression tag |
Leu 734 | - | expression tag |
Ala 735 | - | expression tag |
Gln 736 | - | expression tag |
Ser 737 | - | expression tag |
Asn 738 | - | expression tag |
Ser 739 | - | expression tag |
Leu 740 | - | expression tag |
Glu 741 | - | expression tag |
Val 742 | - | expression tag |
Leu 743 | - | expression tag |
Phe 744 | - | expression tag |
Gln 745 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 684 | - | expression tag |
Gly 685 | - | expression tag |
Ser 686 | - | expression tag |
Glu 687 | - | expression tag |
Asn 688 | - | expression tag |
Leu 689 | - | expression tag |
Tyr 690 | - | expression tag |
Phe 691 | - | expression tag |
Gln 692 | - | expression tag |
Gly 693 | - | expression tag |
Gly 694 | - | expression tag |
Gly 695 | - | expression tag |
Ser 696 | - | expression tag |
Ala 697 | - | expression tag |
Ala 698 | - | expression tag |
Gln 699 | - | expression tag |
Leu 700 | - | expression tag |
Lys 701 | - | expression tag |
Lys 702 | - | expression tag |
Lys 703 | - | expression tag |
Leu 704 | - | expression tag |
Gln 705 | - | expression tag |
Ala 706 | - | expression tag |
Leu 707 | - | expression tag |
Lys 708 | - | expression tag |
Lys 709 | - | expression tag |
Lys 710 | - | expression tag |
Asn 711 | - | expression tag |
Ala 712 | - | expression tag |
Gln 713 | - | expression tag |
Leu 714 | - | expression tag |
Lys 715 | - | expression tag |
Trp 716 | - | expression tag |
Lys 717 | - | expression tag |
Leu 718 | - | expression tag |
Gln 719 | - | expression tag |
Ala 720 | - | expression tag |
Leu 721 | - | expression tag |
Lys 722 | - | expression tag |
Lys 723 | - | expression tag |
Lys 724 | - | expression tag |
Leu 725 | - | expression tag |
Ala 726 | - | expression tag |
Gln 727 | - | expression tag |
Ser 728 | - | expression tag |
Asn 729 | - | expression tag |
Ser 730 | - | expression tag |
Leu 731 | - | expression tag |
Glu 732 | - | expression tag |
Val 733 | - | expression tag |
Leu 734 | - | expression tag |
Phe 735 | - | expression tag |
Gln 736 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Thr -1 | - | expression tag |
Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 169780.4 | |
Branched | Number of molecules | 2 |
Total formula weight | 1173.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 171395.9 |