8HGO

The EGF-bound EGFR/HER2 ectodomain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Receptor tyrosine-protein kinase erbB-2	polymer	745	82149.8	1	UniProt (P04626) Pfam (PF21314) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (human)	Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2
2	B (A)	Epidermal growth factor receptor	polymer	736	81075.3	1	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) Pfam (PF21314)	Homo sapiens (human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
3	C (C)	Epidermal growth factor	polymer	57	6555.4	1	UniProt (P01133) Pfam (PF00008)	Homo sapiens (human)	Urogastrone
4	D (D)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G50737AO)
5	E (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

B: 1 - 693 (UniProt: P04626)

PDB	External Database	Details
Gly 694	-	expression tag
Gly 695	-	expression tag
Ser 696	-	expression tag
Glu 697	-	expression tag
Asn 698	-	expression tag
Leu 699	-	expression tag
Tyr 700	-	expression tag
Phe 701	-	expression tag
Gln 702	-	expression tag
Gly 703	-	expression tag
Gly 704	-	expression tag
Gly 705	-	expression tag
Ser 706	-	expression tag
Ala 707	-	expression tag
Gln 708	-	expression tag
Leu 709	-	expression tag
Glu 710	-	expression tag
Lys 711	-	expression tag
Glu 712	-	expression tag
Leu 713	-	expression tag
Gln 714	-	expression tag
Ala 715	-	expression tag
Leu 716	-	expression tag
Glu 717	-	expression tag
Lys 718	-	expression tag
Glu 719	-	expression tag
Asn 720	-	expression tag
Ala 721	-	expression tag
Gln 722	-	expression tag
Leu 723	-	expression tag
Glu 724	-	expression tag
Trp 725	-	expression tag
Glu 726	-	expression tag
Leu 727	-	expression tag
Gln 728	-	expression tag
Ala 729	-	expression tag
Leu 730	-	expression tag
Glu 731	-	expression tag
Lys 732	-	expression tag
Glu 733	-	expression tag
Leu 734	-	expression tag
Ala 735	-	expression tag
Gln 736	-	expression tag
Ser 737	-	expression tag
Asn 738	-	expression tag
Ser 739	-	expression tag
Leu 740	-	expression tag
Glu 741	-	expression tag
Val 742	-	expression tag
Leu 743	-	expression tag
Phe 744	-	expression tag
Gln 745	-	expression tag

A: 1 - 683 (UniProt: P00533)

PDB	External Database	Details
Gly 684	-	expression tag
Gly 685	-	expression tag
Ser 686	-	expression tag
Glu 687	-	expression tag
Asn 688	-	expression tag
Leu 689	-	expression tag
Tyr 690	-	expression tag
Phe 691	-	expression tag
Gln 692	-	expression tag
Gly 693	-	expression tag
Gly 694	-	expression tag
Gly 695	-	expression tag
Ser 696	-	expression tag
Ala 697	-	expression tag
Ala 698	-	expression tag
Gln 699	-	expression tag
Leu 700	-	expression tag
Lys 701	-	expression tag
Lys 702	-	expression tag
Lys 703	-	expression tag
Leu 704	-	expression tag
Gln 705	-	expression tag
Ala 706	-	expression tag
Leu 707	-	expression tag
Lys 708	-	expression tag
Lys 709	-	expression tag
Lys 710	-	expression tag
Asn 711	-	expression tag
Ala 712	-	expression tag
Gln 713	-	expression tag
Leu 714	-	expression tag
Lys 715	-	expression tag
Trp 716	-	expression tag
Lys 717	-	expression tag
Leu 718	-	expression tag
Gln 719	-	expression tag
Ala 720	-	expression tag
Leu 721	-	expression tag
Lys 722	-	expression tag
Lys 723	-	expression tag
Lys 724	-	expression tag
Leu 725	-	expression tag
Ala 726	-	expression tag
Gln 727	-	expression tag
Ser 728	-	expression tag
Asn 729	-	expression tag
Ser 730	-	expression tag
Leu 731	-	expression tag
Glu 732	-	expression tag
Val 733	-	expression tag
Leu 734	-	expression tag
Phe 735	-	expression tag
Gln 736	-	expression tag

C: 1 - 53 (UniProt: P01133)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Thr -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	169780.4
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	171395.9

*Water molecules are not included.