8HFP
Crystal structure of the methyl-CpG-binding domain of SETDB2 in complex with the cysteine-rich domain of C11orf46 protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | ARL14 effector protein | polymer | 77 | 8413.6 | 2 | UniProt (Q8N8R7) Pfam (PF14949) In PDB | Homo sapiens (human) | ARF7 effector protein |
| 2 | C, D | Histone-lysine N-methyltransferase SETDB2 | polymer | 108 | 12569.3 | 2 | UniProt (Q96T68) Pfam (PF01429) In PDB | Homo sapiens (human) | Chronic lymphocytic leukemia deletion region gene 8 protein,Lysine N-methyltransferase 1F,SET domain bifurcated 2 |
| 3 | A, C, B, D | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | A, C, B, D | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 77 (UniProt: Q8N8R7)
C, D: 2 - 108 (UniProt: Q96T68)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Pro 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 41965.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 968.8 | |
| All* | Total formula weight | 42934.6 |
