8HEJ

Crystal structure of Transthyretin in complex with a covalent inhibitor trans-styrylpyrazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transthyretin	polymer	114	12503.0	2	UniProt (P02766) Pfam (PF00576)	Homo sapiens (human)	ATTR,Prealbumin,TBPA
2	C, E (A, B)	2,6-dibromo-4-[(E)-2-(3,5-dimethyl-1H-pyrazol-4-yl)ethenyl]phenol	non-polymer		372.1	2	Chemie (XHF)
3	D, F (A, B)	2,4,6-trifluorobenzaldehyde	non-polymer		160.1	2	Chemie (XHB)
4	G, H (A, B)	water	water		18.0	149	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	25005.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1064.3
All*	Total formula weight	26070.2

*Water molecules are not included.