8HE8
Human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Poly [ADP-ribose] polymerase 2 | polymer | 351 | 39811.7 | 3 | UniProt (Q9UGN5) Pfam (PF02877) Pfam (PF00644) | Homo sapiens (human) | PARP-2,hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,DNA ADP-ribosyltransferase PARP2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2,Protein poly-ADP-ribosyltransferase PARP2 |
| 2 | D, F (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | E, G, H (A, B, C) | 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione | non-polymer | 466.5 | 3 | Chemie (1WI) | |||
| 4 | I, J, K (A, B, C) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A, B, C: 231 - 581 (UniProt: Q9UGN5)
| PDB | External Database | Details |
|---|---|---|
| Ser 349 | Thr 349 | engineered mutation |
| Arg 351 | Leu 351 | engineered mutation |
| Gly 353 | Ser 353 | engineered mutation |
| Leu 354 | Pro 354 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 119435.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1583.7 | |
| All* | Total formula weight | 121018.9 |
