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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HCQ

Cryo-EM structure of endothelin1-bound ETAR-Gq complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(q) subunit alpha-1polymer24628084.81Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37741055.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(E)		scFv16polymer28530363.01Mus musculus
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(L)		Endothelin-1polymer212498.01UniProt (P05305)
Pfam (PF00322)		Homo sapiens (human)Preproendothelin-1,PPET1
6F
(R)		Endothelin-1 receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimerapolymer62269969.91UniProt (P25101)
UniProt (Q9GV45)		Homo sapiens (human)Endothelin receptor type A,ET-A,ETA-R,hET-AR,19kOLase
Sequence modifications
B: 7 - 345 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -5-initiating methionine
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
His 1-expression tag
Gly 2-expression tag
Ser 3-expression tag
Leu 4-expression tag
Leu 5-expression tag
Gln 6-expression tag
Gly 346-expression tag
Ser 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Gly 354-expression tag
Gly 355-expression tag
Gly 356-expression tag
Gly 357-expression tag
Ser 358-expression tag
Ser 359-expression tag
Gly 360-expression tag
Val 361-expression tag
Ser 362-expression tag
Gly 363-expression tag
Trp 364-expression tag
Arg 365-expression tag
Leu 366-expression tag
Phe 367-expression tag
Lys 368-expression tag
Lys 369-expression tag
Ile 370-expression tag
Ser 371-expression tag
R: 20 - 406 (UniProt: P25101)
PDBExternal DatabaseDetails
Met -57-initiating methionine
Asp -56-expression tag
Ser -55-expression tag
Lys -54-expression tag
Gly -53-expression tag
Ser -52-expression tag
Ser -51-expression tag
Gln -50-expression tag
Lys -49-expression tag
Gly -48-expression tag
Ser -47-expression tag
Arg -46-expression tag
Leu -45-expression tag
Leu -44-expression tag
Leu -43-expression tag
Leu -42-expression tag
Leu -41-expression tag
Val -40-expression tag
Val -39-expression tag
Ser -38-expression tag
Asn -37-expression tag
Leu -36-expression tag
Leu -35-expression tag
Leu -34-expression tag
Cys -33-expression tag
Gln -32-expression tag
Gly -31-expression tag
Val -30-expression tag
Val -29-expression tag
Ser -28-expression tag
Asp -27-expression tag
Tyr -26-expression tag
Lys -25-expression tag
Asp -24-expression tag
Asp -23-expression tag
Asp -22-expression tag
Asp -21-expression tag
Val -20-expression tag
Asp -19-expression tag
Met -18-expression tag
Gly -17-expression tag
Gln -16-expression tag
Pro -15-expression tag
Gly -14-expression tag
Asn -13-expression tag
Gly -12-expression tag
Ser -11-expression tag
Ala -10-expression tag
Phe -9-expression tag
Leu -8-expression tag
Leu -7-expression tag
Ala -6-expression tag
Pro -5-expression tag
Asn -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
Ala 0-expression tag
Pro 1-expression tag
Asp 2-expression tag
His 3-expression tag
Asp 4-expression tag
Val 5-expression tag
Thr 6-expression tag
Gln 7-expression tag
Gln 8-expression tag
Arg 9-expression tag
Asp 10-expression tag
Glu 11-expression tag
Glu 12-expression tag
Asn 13-expression tag
Leu 14-expression tag
Tyr 15-expression tag
Phe 16-expression tag
Gln 17-expression tag
Gly 18-expression tag
Ala 19-expression tag
R: 407 - 564 (UniProt: Q9GV45)
PDBExternal DatabaseDetails
Val 407Thr 27conflict
Glu 411Ala 31conflict
Glu 418Gln 38conflict
Ala 422Gly 42conflict
Leu 425Gln 45conflict
Val 434Leu 54conflict
Leu 438Phe 58conflict
Asn 440Ala 60conflict
Ala 442Gly 62conflict
Arg 450Lys 70conflict
Ile 451Val 71conflict
Arg 453Leu 73conflict
Ala 458Gly 78conflict
Ile 461Ala 81conflict
Ala 474Gly 94conflict
Asp 475Phe 95conflict
Ala 478Gly 98conflict
Gln 479Leu 99conflict
Glu 482Met 102conflict
Val 483Ile 103conflict
Val 497Ile 117conflict
Pro 500His 120conflict
Leu 514Ile 134conflict
Asn 515Asp 135conflict
Glu 522Pro 142conflict
Lys 531Gln 151conflict
Ile 545Tyr 165conflict
Thr 551Asn 171conflict
Met 556Leu 176conflict
Ser 564Gly 184conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight179832.7
All*Total formula weight179832.7
*Water molecules are not included.

249697

PDB entries from 2026-02-25

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