8HCK
NMR fragment-based screening against the two PDZ do-mains of MDA-9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Syntenin-1 | polymer | 81 | 8950.4 | 1 | UniProt (O00560) Pfam (PF00595) | Homo sapiens (human) | Melanoma differentiation-associated protein 9,MDA-9,Pro-TGF-alpha cytoplasmic domain-interacting protein 18,TACIP18,Scaffold protein Pbp1,Syndecan-binding protein 1 |
| 2 | B (A) | 4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE | non-polymer | 308.4 | 1 | Chemie (P1Z) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | G (A) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A: 1 - 79 (UniProt: O00560)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 8950.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 684.7 | |
| All* | Total formula weight | 9635.1 |
