8HCH

Crystal structure of mTREX1-Uridine complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Three-prime repair exonuclease 1	polymer	252	27447.2	4	UniProt (Q91XB0)	Mus musculus (house mouse)	3'-5' exonuclease TREX1
2	E, G, I, K (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
3	F, H, J, L (A, B, C, D)	URIDINE	non-polymer		244.2	4	Chemie (URI)
4	M, N, O, P (A, B, C, D)	water	water		18.0	458	Chemie (HOH)

Sequence modifications

A, B, C, D: 10 - 242 (UniProt: Q91XB0)

PDB	External Database	Details
Met -9	-	initiating methionine
Gly -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Val 5	-	expression tag
Pro 6	-	expression tag
Arg 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	109788.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1074.0
All*	Total formula weight	110862.6

*Water molecules are not included.