8HAK
Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 4 (4.5 angstrom resolution)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3.1 | polymer | 135 | 15306.0 | 2 | UniProt (P68431) Pfam (PF00125) | Homo sapiens (human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 2 | B, F (B, F) | Histone H4 | polymer | 102 | 11345.3 | 2 | Pfam (PF15511) UniProt (by SIFTS) (P62805) | Homo sapiens | |
| 3 | C, G (C, G) | Histone H2A type 1-B/E | polymer | 129 | 14034.4 | 2 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 4 | D, H (D, H) | Histone H2B type 1-J | polymer | 125 | 13804.0 | 2 | UniProt (P06899) Pfam (PF00125) | Homo sapiens (human) | Histone H2B.1,Histone H2B.r,H2B/r |
| 5 | I, J (J, K) | DNA (180-mer) | polymer | 180 | 55560.5 | 2 | Homo sapiens | ||
| 6 | K (N) | Histone acetyltransferase p300 | polymer | 796 | 92314.4 | 1 | UniProt (Q09472) Pfam (PF02135) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) Pfam (PF00569) | Homo sapiens (human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300 |
Sequence modifications
N: 1048 - 1836 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Gly 1041 | - | expression tag |
| Ser 1042 | - | expression tag |
| Ser 1043 | - | expression tag |
| Gly 1044 | - | expression tag |
| Ser 1045 | - | expression tag |
| Ser 1046 | - | expression tag |
| Gly 1047 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 312414.8 | |
| All* | Total formula weight | 312414.8 |
