8H7L
Cryo-EM Structure of SARS-CoV-2 BA.2 Spike protein in complex with BA7535
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein | polymer | 1123 | 124554.3 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | S glycoprotein,E2,Peplomer protein |
2 | D, E, F | BA7535 fab heavt chain | polymer | 453 | 49838.1 | 3 | Homo sapiens | ||
3 | G, H, I | BA7535 fab light chain | polymer | 214 | 23431.0 | 3 | Homo sapiens | ||
4 | J, K, L, M, N... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
5 | B, C, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) |
Sequence modifications
A, B, C: 23 - 1143 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Ile 24 | Thr 19 | variant |
- | Leu 24 | deletion |
- | Pro 25 | deletion |
- | Pro 26 | deletion |
Ser 29 | Ala 27 | variant |
Asp 144 | Gly 142 | variant |
Gly 213 | Val 213 | variant |
Asp 339 | Gly 339 | variant |
Phe 371 | Ser 371 | conflict |
Pro 373 | Ser 373 | variant |
Phe 375 | Ser 375 | variant |
Ala 376 | Thr 376 | variant |
Asn 405 | Asp 405 | variant |
Ser 408 | Arg 408 | variant |
Asn 417 | Lys 417 | variant |
Lys 440 | Asn 440 | variant |
Asn 477 | Ser 477 | variant |
Lys 478 | Thr 478 | variant |
Ala 484 | Glu 484 | variant |
Arg 493 | Gln 493 | variant |
Arg 498 | Gln 498 | variant |
Tyr 501 | Asn 501 | variant |
His 505 | Tyr 505 | variant |
Gly 614 | Asp 614 | variant |
Tyr 655 | His 655 | variant |
Lys 679 | Asn 679 | variant |
His 681 | Pro 681 | variant |
Gly 682 | Arg 682 | engineered mutation |
Ser 683 | Arg 683 | engineered mutation |
Ser 685 | Arg 685 | engineered mutation |
Lys 696 | Thr 696 | conflict |
His 698 | Ser 698 | conflict |
Lys 764 | Asn 764 | variant |
Tyr 796 | Asp 796 | variant |
Pro 817 | Phe 817 | conflict |
Pro 892 | Ala 892 | conflict |
Pro 899 | Ala 899 | conflict |
Pro 942 | Ala 942 | conflict |
Asn 950 | Asp 950 | variant |
His 954 | Gln 954 | variant |
Pro 986 | Lys 986 | engineered mutation |
Pro 987 | Val 987 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 593470.3 | |
Branched | Number of molecules | 12 |
Total formula weight | 5092.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2654.5 | |
All* | Total formula weight | 601217.6 |