8H7H
The crystal structure of human abl1 kinase domain in complex with abl1-A-EBA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 277 | 32062.6 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | C, D (A, B) | 5-[3-(6-methoxyisoquinolin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-methyl-N-prop-2-ynyl-pyridine-3-carboxamide | non-polymer | 447.5 | 2 | Chemie (QH9) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 474 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 500 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 224 | - | expression tag |
| Ala 225 | - | expression tag |
| Met 226 | - | expression tag |
| Gly 227 | - | expression tag |
| Ser 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64125.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 895.0 | |
| All* | Total formula weight | 65020.2 |
