8H77

Hsp90-AhR-p23-XAP2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heat shock protein HSP 90-beta	polymer	756	86590.7	2	UniProt (P11499) Pfam (PF13589) Pfam (PF00183) In PDB	Mus musculus (house mouse)	Heat shock 84 kDa,HSP 84,HSP84,Tumor-specific transplantation 84 kDa antigen,TSTA
2	C, D	Prostaglandin E synthase 3	polymer	172	20134.0	2	UniProt (Q9R0Q7) Pfam (PF04969) In PDB	Mus musculus (house mouse)	Cytosolic prostaglandin E2 synthase,cPGES,Hsp90 co-chaperone,Progesterone receptor complex p23,Sid 3177,Telomerase-binding protein p23
3	E	Aryl hydrocarbon receptor	polymer	449	50507.4	1	UniProt (P30561) Pfam (PF00010) Pfam (PF00989) Pfam (PF08447) In PDB	Mus musculus (house mouse)	Ah receptor,AhR
4	F	AH receptor-interacting protein	polymer	339	38744.1	1	UniProt (O08915) Pfam (PF00254) In PDB	Mus musculus (house mouse)	AIP,Aryl-hydrocarbon receptor-interacting protein
5	A, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
6	A, B	BERYLLIUM TRIFLUORIDE ION	non-polymer		66.0	2	Chemie (BEF)

Sequence modifications

A, B: 1 - 724 (UniProt: P11499)

PDB	External Database	Details
Met -31	-	initiating methionine
Gly -30	-	expression tag
Ala -29	-	expression tag
Trp -28	-	expression tag
Ser -27	-	expression tag
His -26	-	expression tag
Pro -25	-	expression tag
Gln -24	-	expression tag
Phe -23	-	expression tag
Glu -22	-	expression tag
Lys -21	-	expression tag
Gly -20	-	expression tag
Gly -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Gly -16	-	expression tag
Gly -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Gly -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Ala -8	-	expression tag
Trp -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
Pro -4	-	expression tag
Gln -3	-	expression tag
Phe -2	-	expression tag
Glu -1	-	expression tag
Lys 0	-	expression tag

C, D: 1 - 160 (UniProt: Q9R0Q7)

PDB	External Database	Details
Met -11	-	initiating methionine
Ala -10	-	expression tag
Glu -9	-	expression tag
Gln -8	-	expression tag
Lys -7	-	expression tag
Leu -6	-	expression tag
Ile -5	-	expression tag
Ser -4	-	expression tag
Glu -3	-	expression tag
Glu -2	-	expression tag
Asp -1	-	expression tag
Leu 0	-	expression tag

E: 1 - 437 (UniProt: P30561)

PDB	External Database	Details
Gly -11	-	expression tag
Pro -10	-	expression tag
Gly -9	-	expression tag
Ala -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Ala -1	-	expression tag
Gly 0	-	expression tag

F: 2 - 330 (UniProt: O08915)

PDB	External Database	Details
Met -8	-	initiating methionine
Ala -7	-	expression tag
Tyr -6	-	expression tag
Pro -5	-	expression tag
Tyr -4	-	expression tag
Asp -3	-	expression tag
Val -2	-	expression tag
Pro -1	-	expression tag
Asp 0	-	expression tag
Tyr 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	302700.9
Non-Polymers*	Number of molecules	4
	Total formula weight	986.4
All*	Total formula weight	303687.3

*Water molecules are not included.