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8H6T

Complex structure of CDK2/Cyclin E1 and a potent, selective small molecule inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Cyclin-dependent kinase 2polymer29834040.41UniProt (P24941)
Pfam (PF00069)
Homo sapiens (human)Cell division protein kinase 2,p33 protein kinase
2B
(B)
G1/S-specific cyclin-E1polymer27231712.91UniProt (P24864)
Pfam (PF00134)
Pfam (PF02984)
Homo sapiens (human)
3C
(A)
(1R,3S)-3-{3-[(pyridin-2-yl)amino]-1H-pyrazol-5-yl}cyclopentyl propan-2-ylcarbamatenon-polymer329.41Chemie (WZZ)
4D
(A)
waterwater18.02Chemie (HOH)
Sequence modifications
A: 1 - 297 (UniProt: P24941)
PDBExternal DatabaseDetails
Pro 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight65753.3
Non-Polymers*Number of molecules1
Total formula weight329.4
All*Total formula weight66082.7
*Water molecules are not included.

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PDB entries from 2025-07-30

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