8H6P
Complex structure of CDK2/Cyclin E1 and a potent, selective macrocyclic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 298 | 34040.4 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (B) | G1/S-specific cyclin-E1 | polymer | 271 | 31655.8 | 1 | UniProt (P24864) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | |
| 3 | C (A) | (7S,10R)-11-oxa-2,4,5,13,17,23-hexaazatetracyclo[17.3.1.1~3,6~.1~7,10~]pentacosa-1(23),3(25),5,19,21-pentaene-12,18-dione | non-polymer | 370.4 | 1 | Chemie (WZU) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 1 - 297 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65696.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 370.4 | |
| All* | Total formula weight | 66066.7 |
