8H0Q
Structure of the GRP14-27-GRPR-Gq complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Gastrin-releasing peptide receptor | polymer | 384 | 43258.7 | 1 | UniProt (P30550) Pfam (PF00001) | Homo sapiens (human) | GRP-R,GRP-preferring bombesin receptor |
| 2 | B (L) | GRP | polymer | 9 | 1066.2 | 1 | Pfam (PF02044) UniProt (by SIFTS) (P07492) | Homo sapiens | |
| 3 | C (A) | G-alpha q | polymer | 361 | 41724.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092) | Homo sapiens | |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 343 | 37771.4 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 5 | E (E) | scFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 6 | F (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 7 | G, H, I (R) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) |
Sequence modifications
R: 1 - 384 (UniProt: P30550)
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gln 131 | Leu 131 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 157959.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1160.0 | |
| All* | Total formula weight | 159119.1 |
