8GZR
Cryo-EM structure of the the NS5-NS3 RNA-elongation complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Genome polyprotein | polymer | 908 | 104189.9 | 1 | UniProt (Q5I3C1) | Dengue virus | |
| 2 | B (B) | Genome polyprotein | polymer | 673 | 74753.4 | 1 | UniProt (A0A6B7HXY7) UniProt (by SIFTS) (Q5I3C1) | Dengue virus | |
| 3 | C (C) | RNA | polymer | 40 | 12802.5 | 1 | synthetic construct | ||
| 4 | D, E, J (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) PubChem (27854) | |||
| 5 | F, G (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | H (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (13792) PubChem (177678424) PubChem (189149) PubChem (439155) PubChem (25210495) PubChem (21125603) PubChem (44361184) PubChem (25203782) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (52224400) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (5284331) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (71170554) PubChem (13231890) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (164157219) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 7 | I, K (A, B) | CYTIDINE-5'-DIPHOSPHATE | non-polymer | 403.2 | 2 | Chemie (CDP) |
Sequence modifications
A: 1 - 900 (UniProt: Q5I3C1)
B: 1 - 619 (UniProt: A0A6B7HXY7)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -53 | - | initiating methionine |
| Gly -52 | - | expression tag |
| Ser -51 | - | expression tag |
| Ser -50 | - | expression tag |
| His -49 | - | expression tag |
| His -48 | - | expression tag |
| His -47 | - | expression tag |
| His -46 | - | expression tag |
| His -45 | - | expression tag |
| His -44 | - | expression tag |
| Ser -43 | - | expression tag |
| Gln -42 | - | expression tag |
| Asp -41 | - | expression tag |
| Pro -40 | - | expression tag |
| Glu -39 | - | expression tag |
| Asn -38 | - | expression tag |
| Leu -37 | - | expression tag |
| Tyr -36 | - | expression tag |
| Phe -35 | - | expression tag |
| Gln -34 | - | expression tag |
| Gly -33 | - | expression tag |
| Ser -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Gly -30 | - | expression tag |
| Ser -29 | - | expression tag |
| Ser -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Ala -26 | - | expression tag |
| Asp -25 | - | expression tag |
| Leu -24 | - | expression tag |
| Thr -23 | - | expression tag |
| Val -22 | - | expression tag |
| Glu -21 | - | expression tag |
| Lys -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Ala -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Val -16 | - | expression tag |
| Thr -15 | - | expression tag |
| Trp -14 | - | expression tag |
| Glu -13 | - | expression tag |
| Glu -12 | - | expression tag |
| Glu -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 135 | Ser 1608 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 191745.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1486.4 | |
| All* | Total formula weight | 193232.2 |
