8GZQ

Cryo-EM structure of the NS5-NS3-SLA complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Genome polyprotein	polymer	908	104189.9	1	UniProt (Q5I3C1) Pfam (PF01728) Pfam (PF00972) Pfam (PF20483) In PDB	Dengue virus
2	B	Genome polyprotein	polymer	673	74753.4	1	UniProt (A0A6B7HXY7) Pfam (PF00949) Pfam (PF07652) Pfam (PF20907) UniProt (by SIFTS) (Q5I3C1) In PDB	Dengue virus
3	S	RNA	polymer	168	54128.9	1		synthetic construct
4	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	S	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)

Sequence modifications

A: 1 - 900 (UniProt: Q5I3C1)

PDB	External Database	Details
Gly -7	-	expression tag
Pro -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

B: 1 - 619 (UniProt: A0A6B7HXY7)

PDB	External Database	Details
Met -53	-	initiating methionine
Gly -52	-	expression tag
Ser -51	-	expression tag
Ser -50	-	expression tag
His -49	-	expression tag
His -48	-	expression tag
His -47	-	expression tag
His -46	-	expression tag
His -45	-	expression tag
His -44	-	expression tag
Ser -43	-	expression tag
Gln -42	-	expression tag
Asp -41	-	expression tag
Pro -40	-	expression tag
Glu -39	-	expression tag
Asn -38	-	expression tag
Leu -37	-	expression tag
Tyr -36	-	expression tag
Phe -35	-	expression tag
Gln -34	-	expression tag
Gly -33	-	expression tag
Ser -32	-	expression tag
Ser -31	-	expression tag
Gly -30	-	expression tag
Ser -29	-	expression tag
Ser -28	-	expression tag
Gly -27	-	expression tag
Ala -26	-	expression tag
Asp -25	-	expression tag
Leu -24	-	expression tag
Thr -23	-	expression tag
Val -22	-	expression tag
Glu -21	-	expression tag
Lys -20	-	expression tag
Ala -19	-	expression tag
Ala -18	-	expression tag
Asp -17	-	expression tag
Val -16	-	expression tag
Thr -15	-	expression tag
Trp -14	-	expression tag
Glu -13	-	expression tag
Glu -12	-	expression tag
Glu -11	-	expression tag
Ala -10	-	expression tag
Glu -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Ala 135	Ser 1608	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	233072.2
Non-Polymers*	Number of molecules	3
	Total formula weight	574.0
All*	Total formula weight	233646.2

*Water molecules are not included.