8GZ3
Structure of human phagocyte NADPH oxidase in the resting state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome b-245 light chain | polymer | 195 | 21005.4 | 1 | UniProt (P13498) Pfam (PF05038) | Homo sapiens (human) | Cytochrome b(558) alpha chain,Cytochrome b558 subunit alpha,Neutrophil cytochrome b 22 kDa polypeptide,Superoxide-generating NADPH oxidase light chain subunit,p22 phagocyte B-cytochrome,p22-phox,p22phox |
| 2 | B (B) | Cytochrome b-245 heavy chain | polymer | 570 | 65412.7 | 1 | UniProt (P04839) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) | Homo sapiens (human) | CGD91-phox,Cytochrome b(558) subunit beta,Cytochrome b558 subunit beta,Heme-binding membrane glycoprotein gp91phox,NADPH oxidase 2,Neutrophil cytochrome b 91 kDa polypeptide,Superoxide-generating NADPH oxidase heavy chain subunit,gp91-1,gp91-phox,p22 phagocyte B-cytochrome |
| 3 | C (L) | 7D5 Fab light chain | polymer | 211 | 17975.1 | 1 | Mus musculus | ||
| 4 | D (H) | 7D5 Fab heavy chain | polymer | 215 | 18315.5 | 1 | Mus musculus | ||
| 5 | E (N) | Green Fluorescent Protein, Anti-Fab (kappa) nanobody[TP1170] chimera | polymer | 414 | 46217.3 | 1 | Vicugna pacos | ||
| 6 | F (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | G (B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 8 | H, I (B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 9 | J, K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | L (B) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 1 | Chemie (LBN) | |||
| 11 | M (B) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 195 (UniProt: P13498)
| PDB | External Database | Details |
|---|---|---|
| Ala 174 | Val 174 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 168926.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3221.0 | |
| All* | Total formula weight | 172733.6 |
